About: Gammaherpesviral Gene Expression and Virion Composition Are Broadly Controlled by Accelerated mRNA Degradation

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About: Gammaherpesviral Gene Expression and Virion Composition Are Broadly Controlled by Accelerated mRNA Degradation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gammaherpesviral Gene Expression and Virion Composition Are Broadly Controlled by Accelerated mRNA Degradation
Creator	Clyde, Karen Coscoy, Laurent Glaunsinger, Britt Abernathy, Emma Burlingame, Al Yeasmin, Rukhsana Faye Van Dyk, Linda Krug, Laurie
Source	Medline; PMC
abstract	Lytic gammaherpesvirus infection restricts host gene expression by promoting widespread degradation of cytoplasmic mRNA through the activity of the viral endonuclease SOX. Though generally assumed to be selective for cellular transcripts, the extent to which SOX impacts viral mRNA stability has remained unknown. We addressed this issue using the model murine gammaherpesvirus MHV68 and, unexpectedly, found that all stages of viral gene expression are controlled through mRNA degradation. Using both comprehensive RNA expression profiling and half-life studies we reveal that the levels of the majority of viral mRNAs but not noncoding RNAs are tempered by MHV68 SOX (muSOX) activity. The targeting of viral mRNA by muSOX is functionally significant, as it impacts intracellular viral protein abundance and progeny virion composition. In the absence of muSOX-imposed gene expression control the viral particles display increased cell surface binding and entry as well as enhanced immediate early gene expression. These phenotypes culminate in a viral replication defect in multiple cell types as well as in vivo, highlighting the importance of maintaining the appropriate balance of viral RNA during gammaherpesviral infection. This is the first example of a virus that fails to broadly discriminate between cellular and viral transcripts during host shutoff and instead uses the targeting of viral messages to fine-tune overall gene expression.
has issue date	2014-01-16(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1003882
bibo:pmid	24453974
has license	cc-by
sha1sum (hex)	a2d455f2d873e1be7f2db4b069b6e40f3faf168b
schema:url	https://doi.org/10.1371/journal.ppat.1003882
resource representing a document's title	Gammaherpesviral Gene Expression and Virion Composition Are Broadly Controlled by Accelerated mRNA Degradation
has PubMed Central identifier	PMC3894220
has PubMed identifier	24453974
schema:publication	PLoS Pathog
resource representing a document's body	covid:a2d455f2d873e1be7f2db4b069b6e40f3faf168b#body_text
is schema:about of	named entity 'COMPOSITION' named entity 'half-life' named entity 'targeting' named entity 'Composition' named entity 'Virion' named entity 'GENE EXPRESSION' named entity 'ABSENCE OF' named entity 'LYTIC' named entity 'UNKNOWN' named entity 'CYTOPLASMIC' named entity 'VIRAL MRNA' named entity 'VIRAL PROTEIN' named entity 'VIRAL REPLICATION' named entity 'PROMOTING' named entity 'SOX' named entity 'DISCRIMINATE' covid:arg/a2d455f2d873e1be7f2db4b069b6e40f3faf168b named entity 'FINE' named entity 'SELECTIVE' named entity 'BALANCE' named entity 'THESE' named entity 'BUT' named entity 'DEFECT' named entity 'USING' named entity 'GAMMAHERPESVIRUS' named entity 'VIRAL PARTICLES' named entity 'MRNA DEGRADATION' named entity 'MRNA DEGRADATION' named entity 'HALF-LIFE' named entity 'WIDESPREAD' named entity 'CELLULAR' named entity 'REVEAL' named entity 'TRANSCRIPTS' named entity 'ALL STAGES' named entity 'IN VIVO' named entity 'CONTROLLED BY' named entity 'RNA EXPRESSION' named entity 'HOST' named entity 'USES' named entity 'MESSAGES' named entity 'TARGETING' named entity 'OVERALL' named entity 'SIGNIFICANT' named entity 'EXAMPLE' named entity 'RESTRICTS' named entity 'MODEL' named entity 'DISPLAY' named entity 'INTRACELLULAR' named entity 'RNAS' named entity 'ISSUE' named entity 'COMPOSITION' named entity 'MAINTAINING' named entity 'ENTRY' named entity 'ASSUMED' named entity 'MRNA' named entity 'IMPACTS' named entity 'FAILS' named entity 'PROTEIN ABUNDANCE' named entity 'MRNA STABILITY' named entity 'PHENOTYPES' named entity 'ENDONUCLEASE' named entity 'APPROPRIATE' named entity 'CELL TYPES' named entity 'CONTROL' named entity 'HIGHLIGHTING' named entity 'VIRUS' named entity 'DEGRADATION' named entity 'STUDIES' named entity 'VIRAL GENE EXPRESSION' named entity 'CELL SURFACE BINDING' named entity 'ACTIVITY' named entity 'MULTIPLE' named entity 'FOUND' named entity 'COMPREHENSIVE'

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