About: Mouse Hepatitis Virus 3 Binding to Macrophages Correlates with Resistance to Experimental Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mouse Hepatitis Virus 3 Binding to Macrophages Correlates with Resistance to Experimental Infection
Creator	Pereira, C Moreira, C Butantan, De Franco, M Pereira, Instituto Tsuhako, M
source	Medline; PMC
abstract	Mouse hepatitis virus 3 (MHV3) infection of A/J and BALB/c mice has been used as a model of resistance/susceptibility. A/J mice recover from a mild disease after 4–6 days of infection and the BALB/c mice develop an acute hepatitis and die after 3–4 days of infection. In view of studying the MHV3 binding to cells or cell extracts, we performed an enzyme‐linked immunosorbent assay‐like virus‐binding assay, preparing microplates with L929 cells, A/J or BALB/c mouse macrophages and also with proteins extracted from these cells. Higher MHV3 bindings were observed to proteins of BALB/c macrophages than to the A/J ones. The interferon‐γ (IFN‐γ) activation led to a reduction of MHV3 binding only to proteins of resistant A/J mouse macrophages. Our experiments contribute to the hypothesis that IFN‐γ activation of macrophages plays an important role against MHV3 infection by downregulating the expression of viral receptors.
has issue date	2008-10-09(xsd:dateTime)
bibo:doi	10.1111/j.1365-3083.2005.01616.x
bibo:pmid	15953191
has license	no-cc
sha1sum (hex)	a30a173ea3624f55cce0f5ee7ca9979910d0b2d7
schema:url	https://doi.org/10.1111/j.1365-3083.2005.01616.x
resource representing a document's title	Mouse Hepatitis Virus 3 Binding to Macrophages Correlates with Resistance to Experimental Infection
has PubMed Central identifier	PMC7169576
has PubMed identifier	15953191
schema:publication	Scand J Immunol
resource representing a document's body	covid:a30a173ea3624f55cce0f5ee7ca9979910d0b2d7#body_text
is schema:about of	named entity 'acute hepatitis' named entity 'cells' named entity 'reduction' named entity 'macrophages' named entity 'cell' named entity 'DAYS' named entity 'MOUSE HEPATITIS VIRUS' named entity 'RESISTANCE' named entity 'PROTEINS' named entity 'INFECTION' named entity 'INTERFERON' named entity 'RECOVER' named entity 'MILD DISEASE' covid:arg/a30a173ea3624f55cce0f5ee7ca9979910d0b2d7 named entity 'proteins' named entity 'bindings' named entity 'binding' named entity 'susceptibility' named entity 'model' named entity 'macrophages' named entity 'IFN-g' named entity 'Resistance' named entity 'L929' named entity 'mice' named entity 'macrophages' named entity 'downregulating' named entity 'infection' named entity 'Infection' named entity 'optical density' named entity 'receptor' named entity 'Protein' named entity 'glycoprotein' named entity 'São Paulo' named entity 'macrophage' named entity 'virus replication' named entity 'exudate' named entity 'titration' named entity 'encephalitis' named entity 'virus' named entity 'plaque assay' named entity 'macrophages' named entity 'macrophage' named entity 'membrane fusion' named entity 'cellular level' named entity 'virus' named entity 'peritoneal' named entity 'macrophages' named entity 'virus' named entity 'tissue tropism' named entity 'exudate' named entity 'viral particles' named entity 'infection' named entity 'cell membrane' named entity 'macrophages' named entity 'virus' named entity 'macrophages' named entity 'Virus' named entity 'protein' named entity 'scientific investigation' named entity 'cell lysis' named entity 'cell membrane' named entity 'Brazil' named entity 'IFN-g' named entity 'IFN-g' named entity 'antigen' named entity 'heterogeneity' named entity 'virus' named entity 'macrophages' named entity 'IFN-g' named entity 'quantitative biology' named entity 'downregulation' named entity 'IFN-g' named entity 'pathological process' named entity 'exudate' named entity 'virus' named entity 'IFN-g'

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