About: Biodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging

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About: Biodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Biodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging
Creator	Liu, Qiang Huang, Weijin Wang, Youchun Fan, Changfa Li, Baowen Li, Qianqian Liu, Susu Wu, Xi Zhou, Shuya
Source	Medline; PMC
abstract	As concerns increase about adenovirus type 5 (Ad5) being a safe gene transfer vector, it is important to evaluate its distribution, residence time, and possible toxicity in immunodeficient populations. To characterize the potential risk associated with different Ad5 vector delivery modes, we used immunocompetent and immunodeficient Rag2 (−/−) animals to establish mouse and rat models that could be monitored with bioluminescent imaging following intramuscular or intravascular infection with an engineered replication-incompetent Ad5 virus carrying the firefly luciferase gene (Ad5-Fluc). The Ad5 vector was less well-tolerated by Rag2 (−/−) animals than by wildtype ones, with delayed residence time, wider virus dissemination, less weight gain, and relatively severe pathological changes. In intravascularly Ad5-Fluc-infected Rag2 (−/−) mice, systemic virus dissemination extended from the abdomen to the limbs and head on day 9 post-infection. Additionally, significant increases in plasma TNF-α and IFN-γ, which may be important factors in the heightened immunopathology in the liver and brain, were detected in the Rag2 (−/−) mice 30 days after intravascular delivery. The Ad5 vector was better tolerated after intramuscular delivery than after intravascular delivery. Ad5-Fluc/Rag2 (−/−) mice and rats can be used as reliable models of an immunodeficient population in which to evaluate the safety of Ad5-vectored vaccines or gene therapy products.
has issue date	2017-06-15(xsd:dateTime)
bibo:doi	10.1038/s41598-017-03852-0
bibo:pmid	28620164
has license	cc-by
sha1sum (hex)	a30cef8b3428aa804aa2cbf0ec0303827bb09514
schema:url	https://doi.org/10.1038/s41598-017-03852-0
resource representing a document's title	Biodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging
has PubMed Central identifier	PMC5472566
has PubMed identifier	28620164
schema:publication	Sci Rep
resource representing a document's body	covid:a30cef8b3428aa804aa2cbf0ec0303827bb09514#body_text
is schema:about of	named entity 'immunodeficient' named entity 'models' named entity 'gene' named entity 'populations' named entity 'liver' named entity 'immunodeficient' named entity 'population' named entity 'detected' named entity 'OPEN' named entity 'VIRUS' named entity 'ENGINEERED' named entity 'POPULATIONS' named entity 'LIMBS' named entity 'BETTER' named entity 'AND BRAIN' named entity 'DAYS' named entity 'SAFETY' named entity 'CHANGES' named entity 'VACCINES' named entity 'HEAD' named entity 'MONITORED' named entity 'DETECTED' named entity 'LUCIFERASE GENE' named entity 'SYSTEMIC' named entity 'EVALUATE' named entity 'SEVERE' named entity 'INCREASE' named entity 'DELAYED' named entity 'CONCERNS' named entity 'ABDOMEN' named entity 'PATHOLOGICAL' named entity 'BIODISTRIBUTION' named entity 'POPULATION' named entity 'DAY' named entity 'INFECTION' named entity 'FIREFLY LUCIFERASE' named entity 'USED' named entity 'PRODUCTS' named entity 'IMMUNOPATHOLOGY' named entity 'ITS' named entity 'TNF' named entity 'ABOUT' named entity 'CARRYING' named entity 'RATS' named entity 'IMMUNODEFICIENT' named entity 'MICE' named entity 'DIFFERENT' named entity 'BEING' named entity 'RELIABLE' named entity 'RAG2' named entity 'INFECTED' named entity 'POSSIBLE' named entity 'TO CHARACTERIZE' named entity 'REPLICATION' named entity 'ESTABLISH' named entity 'RAT' named entity 'TOXICITY' named entity 'FOLLOWING' named entity 'RATS' named entity 'DETECTED' named entity 'IMAGING' named entity 'ADENOVIRUS TYPE 5' named entity 'POTENTIAL' named entity 'MICE' named entity 'EXTENDED' named entity 'RESIDENCE TIME' named entity 'NORMAL' named entity 'IMAGING' named entity 'MODELS' named entity 'INTRAMUSCULAR' named entity 'OPEN' named entity 'ANIMALS' named entity 'HEIGHTENED'

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