About: Highly pathogenic porcine reproductive and respiratory syndrome virus infection results in acute lung injury of the infected pigs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Highly pathogenic porcine reproductive and respiratory syndrome virus infection results in acute lung injury of the infected pigs
Creator	Wang, Lin Yang, Hanchun Chen, Zhi Hu, Yanxin Han, Deping Li, Limin Ma, Haiyan Teng, Kedao Tian, Haiyan
Source	Elsevier; Medline; PMC
abstract	Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) was firstly characterized in 2006 in China. The virus has caused great economic loss to the Chinese swine production during the past years. Herein, we experimentally infected SPF pigs using two strains of PRRSV with different pathogenicity and observed the lung pathological changes looking for new sights on the possible pathogenesis associated with the virulence of HP-PRRSV. The results indicated that the HP-PRRSV-infected pigs died and exhibited severe pathological changes of lungs featuring increased neutrophils, mast cells and mononuclear macrophages, compared with the pigs inoculated with low pathogenic (LP-) PRRSV. Furthermore, the pigs infected with HP-PRRSV showed the higher levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interleukin (IL)-8 and histamine, leukotriene B4 (LTB4), platelet activation factor (PAF) in sera than those inoculated with LP-PRRSV. Additionally, the fibrosis of lung was observed in the HP-PRRSV-infected pigs. At present, our findings suggest that the aberrant immune responses triggered by HP-PRRSV infection are closely related to acute lung injury (ALI), and especially the pathological changes in lung vascular system are of particular significance. These associated pathological changes of lung are in part responsible for the additional morbidity and mortality observed in HP-PRRSV infection.
has issue date	2014-03-14(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2013.12.022
bibo:pmid	24472226
has license	no-cc
sha1sum (hex)	a32020d9886c687640acf1c93541f64b6bfeb05a
schema:url	https://doi.org/10.1016/j.vetmic.2013.12.022
resource representing a document's title	Highly pathogenic porcine reproductive and respiratory syndrome virus infection results in acute lung injury of the infected pigs
has PubMed Central identifier	PMC7127595
has PubMed identifier	24472226
schema:publication	Vet Microbiol
resource representing a document's body	covid:a32020d9886c687640acf1c93541f64b6bfeb05a#body_text
is schema:about of	named entity 'histopathological' named entity 'proinflammatory cytokines' named entity 'ALI' named entity 'inflammatory cell' named entity 'immune responses' named entity 'China' named entity 'ALI' named entity 'PBS' named entity 'cytokines' named entity 'macrophages' named entity 'TNF-a' named entity 'Viral titers' named entity 'respiratory tract' named entity 'IL-1b' named entity 'proinflammatory cytokines' named entity 'China' named entity 'stem cells' named entity 'clinical treatment' named entity 'infection' named entity 'Alveolar epithelial cells' named entity 'mononuclear phagocytes' named entity 'tachycardia' named entity 'pyrosis' named entity 'ALI' named entity 'serum' named entity 'alveolar epithelial cells' named entity 'depression' named entity 'control group' named entity 'serum samples' named entity 'lungs' named entity 'vasculitis' named entity 'ALI' named entity 'neutrophils' named entity '5.0' named entity 'primary antibody' named entity 'mitochondrial' named entity 'histopathological' named entity 'pneumonia' named entity 'neutrophils' named entity 'IL-8' named entity 'viremia' named entity 'ARDS' named entity 'dyspnea' named entity 'edema' named entity 'alveolar' named entity 'immune cells' named entity 'viral infection' named entity 'alveolar spaces' named entity 'chemokines' named entity 'diarrhea' named entity 'ALI' named entity 'fibrosis' named entity 'inflammatory cells' named entity 'GraphPad Prism' named entity 'TNF-a' named entity 'vascular permeability' named entity 'left lung' named entity 'significant difference' named entity 'virus infection' named entity 'viruses' named entity 'interstitial pneumonia' named entity 'exudation' named entity 'thrombus' named entity 'Chicken' named entity 'immune cells' named entity 'lungs' named entity 'alveolar' named entity 'type II' named entity 'ALI' named entity 'histamine' named entity 'tissue repair' named entity 'dyspnea' named entity 'virus infection'

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