About: Bioproduction of ribavirin by green microbial biotransformation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bioproduction of ribavirin by green microbial biotransformation
Creator	De Benedetti, Eliana Lozano, Mario Rivero, Cintia Trelles, Jorge
Source	Elsevier; Medline; PMC
abstract	Ribavirin is an antiviral compound widely used in Hepatitis C Virus therapy. Biotransformation of this nucleoside analogue using Escherichia coli ATCC 12407 as biocatalyst is herein reported. Reaction parameters such as microorganism amounts, substrate ratio and temperature were optimized reaching conversion yields of 86%. Biocatalyst stability was enhanced by immobilization in agarose matrix. This immobilized biocatalyst was able to be reused for more than 270 h and could be stored during more than 4 months without activity loss. Batch and packed-bed reactors based on a stabilized biocatalyst were assayed for bioprocess scale-up. A continuous sustainable bioprocess was evaluated using a prototype packed-bed reactor, which allowed to produce 95 mg of ribavirin. Finally, in this work an efficient green bioprocess for ribavirin bioproduction using a stabilized biocatalyst was developed.
has issue date	2015-03-27(xsd:dateTime)
bibo:doi	10.1016/j.procbio.2015.03.015
bibo:pmid	32288593
has license	no-cc
sha1sum (hex)	a342694e9f6d98e0f09ec3c33221ead13095bb18
schema:url	https://doi.org/10.1016/j.procbio.2015.03.015
resource representing a document's title	Bioproduction of ribavirin by green microbial biotransformation
has PubMed Central identifier	PMC7108421
has PubMed identifier	32288593
schema:publication	Process Biochem
resource representing a document's body	covid:a342694e9f6d98e0f09ec3c33221ead13095bb18#body_text
is schema:about of	named entity 'bioprocess' named entity 'loss' named entity 'reactor' named entity 'sustainable' named entity 'compound' named entity 'ribavirin' covid:arg/a342694e9f6d98e0f09ec3c33221ead13095bb18 named entity 'conversion' named entity 'agarose' named entity 'antiviral' named entity 'scale-up' named entity 'therapy' named entity 'Hepatitis C Virus' named entity 'bioprocess' named entity 'immobilized' named entity 'agarose' named entity 'nucleoside analogue' named entity 'biocatalyst' named entity 'Biotransformation' named entity 'Biochemistry' named entity 'biotransformation' named entity 'culture media' named entity 'microorganism' named entity 'microorganism' named entity 'sodium phosphate' named entity 'biotransformation' named entity 'initial condition' named entity 'nucleoside salvage' named entity 'anticancer drug' named entity 'phosphate' named entity 'microorganisms' named entity 'nucleoside analogue' named entity 'Ribavirin' named entity '30 mM' named entity 'w/v' named entity 'ion trap' named entity 'ribavirin' named entity 'p-value' named entity 'silica gel' named entity 'biotransformation' named entity 'active transport' named entity 'biocatalysts' named entity 'biocatalysts' named entity 'environmentally friendly' named entity 'ribavirin' named entity 'ribavirin' named entity 'biotransformation' named entity 'biotransformation' named entity 'ribavirin' named entity 'biocatalysts' named entity 'biocatalytic' named entity 'Ribavirin' named entity 'deoxyribose' named entity 'Nucleosides' named entity 'reaction time' named entity 'SARS' named entity 'CFU' named entity 'catalytic efficiency' named entity 'Escherichia coli' named entity 'carbon' named entity 'substrate' named entity 'ribavirin' named entity 'batch reactor' named entity 'reaction conditions' named entity 'ATCC' named entity 'data analysis' named entity 'reaction conditions' named entity 'screening assay' named entity 'preparative TLC' named entity 'Germany' named entity 'biocatalyst' named entity 'ribavirin' named entity 'genetic engineering' named entity 'Green chemical' named entity 'Microorganism' named entity 'ribavirin' named entity 'biotransformations' named entity 'E. coli'

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