About: In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV2 genomic data

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About: In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV2 genomic data Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV2 genomic data
Creator	Obajuluwa, Adejoke Obajuluwa, Tiwalola Okiki, Pius
source	ArXiv
abstract	The recent zoonotic coronavirus virus outbreak of a novel type [COVID 19] has necessitated the adequate understanding of the evolutionary pathway of zoonotic viruses which adversely affects human populations for therapeutic constructs to combat the pandemic now and in the future. We analyzed conserved domains of the severe acute respiratory coronavirus 2 [SARS-CoV2] for possible targets of viral entry inhibition in host cells, evolutionary relationship of human coronavirus [229E] and zoonotic coronaviruses with SAR-CoV2 as well as evolutionary relationship between selected SARS-CoV 2 genomic data. Conserved domains with antagonistic action on host innate antiviral cellular mechanisms in SARS-CoV 2 include nsp 11, nsp 13 etc. Also, multiple sequence alignments of the spike [S] gene protein of selected candidate zoonotic coronaviruses alongside the S gene protein of the SARs-CoV2 revealed closest evolutionary relationship [95.6%] with pangolin coronaviruses [S] gene. Clades formed between Wuhan SARS-CoV2 phylogeny data and five others suggests viral entry trajectory while revealing genomic and protein SARS CoV 2 data from Philippines as early ancestors. Therefore, phylogeny of SARS-CoV 2 genomic data suggests profiling in diverse populations with and without the outbreak alongside migration history and racial background for mutation tracking and dating of viral subtype divergence which is essential for effective management of present and future zoonotic coronavirus outbreaks.
has issue date	2020-05-06(xsd:dateTime)
has license	arxiv
sha1sum (hex)	a35064054d67371db1eec223c86e7cef21deca2c
resource representing a document's title	In-silico nucleotide and protein analyses of S-gene region in selected zoonotic coronaviruses reveal conserved domains and evolutionary emergence with trajectory course of viral entry from SARS-CoV2 genomic data
resource representing a document's body	covid:a35064054d67371db1eec223c86e7cef21deca2c#body_text
is schema:about of	named entity 'mechanisms' named entity 'future' named entity 'conserved domains' named entity 'viral entry' named entity 'COMBAT' named entity 'TARGETS' named entity 'GENOMIC DATA' named entity 'ZOONOTIC' named entity 'SARS-COV' named entity 'ACTION' named entity 'CORONAVIRUSES' named entity 'CANDIDATE' named entity 'human populations' named entity 'gene' named entity 'severe' named entity 'type' named entity 'protein' named entity 'outbreak' named entity 'SARS-CoV2' named entity 'Wuhan' named entity 'evolutionary relationship' named entity 'SARS-CoV' named entity 'protein' named entity 'conserved domains' named entity 'SARS-CoV' named entity 'viruses' named entity 'genomic data' named entity 'evolution' named entity 'ATPase' named entity 'Recombination' named entity 'viruses' named entity 'EMBOSS' named entity 'betacoronavirus' named entity 'RNA' named entity 'recombination' named entity 'MERS-CoV' named entity 'mouse hepatitis virus' named entity 'nsp' named entity 'receptor binding domain' named entity 'MERS' named entity 'nsp' named entity 'SARS-CoV' named entity 'coronaviruses' named entity 'Protein sequence alignment' named entity 'pandemics' named entity 'transcription' named entity 'viruses' named entity 'pangolin' named entity 'genetic variability' named entity 'cell cycle' named entity 'activity-dependent mechanisms' named entity 'receptor binding' named entity 'DNA replication' named entity 'enveloped viruses' named entity 'spike proteins' named entity 'RNA' named entity 'spike proteins' named entity 'conserved domains' named entity 'MHV' named entity 'SARS-CoV' named entity 'palm civet' named entity 'genomic data' named entity 'Coronavirus' named entity 'receptor' named entity 'glycoprotein' named entity 'viral infections' named entity 'in-vivo' named entity 'RBDs' named entity 'SARS-CoV2' named entity 'drug development' named entity 'Bat' named entity 'SARS-CoV2' named entity 'natural selection' named entity 'ubiquitin-proteasome' named entity 'coronavirus' named entity 'MHV' named entity 'public health' named entity 'RNA viruses' named entity 'recombinants' named entity 'ACE2 receptor' named entity 'Coronaviridae' named entity 'conserved domains' named entity 'Pangolin' named entity 'homology' named entity 'cross-species'

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