About: In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
Creator	Keyaerts, Els Maes, Piet Vijgen, Leen Neyts, Johan Ranst, Marc
source	Elsevier; Medline; PMC
abstract	Abstract We report on chloroquine, a 4-amino-quinoline, as an effective inhibitor of the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro. Chloroquine is a clinically approved drug effective against malaria. We tested chloroquine phosphate for its antiviral potential against SARS-CoV-induced cytopathicity in Vero E6 cell culture. Results indicate that the IC50 of chloroquine for antiviral activity (8.8±1.2μM) was significantly lower than its cytostatic activity; CC50 (261.3±14.5μM), yielding a selectivity index of 30. The IC50 of chloroquine for inhibition of SARS-CoV in vitro approximates the plasma concentrations of chloroquine reached during treatment of acute malaria. Addition of chloroquine to infected cultures could be delayed for up to 5h postinfection, without an important drop in antiviral activity. Chloroquine, an old antimalarial drug, may be considered for immediate use in the prevention and treatment of SARS-CoV infections.
has issue date	2004-10-08(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2004.08.085
bibo:pmid	15351731
has license	els-covid
sha1sum (hex)	a37310720a8f5c49c5cd7f8e198f30768a61ecf2
schema:url	https://doi.org/10.1016/j.bbrc.2004.08.085
resource representing a document's title	In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
has PubMed Central identifier	PMC7092815
has PubMed identifier	15351731
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:a37310720a8f5c49c5cd7f8e198f30768a61ecf2#body_text
is schema:about of	named entity 'prevention' named entity 'Chloroquine' named entity 'antiviral' named entity 'plasma' named entity 'severe acute respiratory syndrome coronavirus' named entity 'severe acute respiratory syndrome coronavirus' named entity 'chloroquine' named entity 'inhibition' covid:arg/a37310720a8f5c49c5cd7f8e198f30768a61ecf2 named entity 'antimalarial drug' named entity 'reached' named entity 'cell culture' named entity 'inhibitor' named entity 'antiviral' named entity 'severe acute respiratory syndrome coronavirus' named entity 'quinoline' named entity '1.2' named entity 'antiviral' named entity 'SARS-CoV' named entity 'Vero E6' named entity 'antiviral activity' named entity 'approved drug' named entity 'SARS-CoV' named entity 'severe acute respiratory syndrome coronavirus' named entity 'chloroquine' named entity 'adsorption' named entity 'interferon' named entity 'HIV type 1' named entity 'viral replication' named entity 'centrifugation' named entity 'formazan' named entity 'etiology' named entity 'immune-mediated' named entity 'chloroquine' named entity 'Belgium' named entity 'infection' named entity 'antiviral effect' named entity 'inflammatory' named entity 'Coronaviridae' named entity 'virus' named entity 'viruses' named entity 'virus' named entity 'Belgium' named entity 'cytopathic effect' named entity 'chloroquine' named entity 'RNA' named entity 'niclosamide' named entity 'Taqman' named entity 'chloroquine' named entity 'ribavirin' named entity 'insoluble' named entity 'Applied Biosystems' named entity 'upper respiratory tract' named entity 'SARS' named entity 'Interferon' named entity 'HCoV) OC43' named entity 'immunodeficiency' named entity 'SARS' named entity 'TaqMan' named entity 'infection' named entity 'viral RNA' named entity 'chloroquine' named entity 'TaqMan' named entity 'antiviral activity' named entity 'SARS' named entity 'SARS' named entity 'SARS' named entity 'replicase' named entity 'Severe acute respiratory syndrome' named entity 'chloroquine' named entity 'plasma' named entity 'HIV-1' named entity 'supernatant' named entity 'tetrazolium' named entity 'Vero E6' named entity 'virus' named entity '229E'

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