About: Chronological Changes of Viral Shedding in Adult Inpatients with COVID-19 in Wuhan, China

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About: Chronological Changes of Viral Shedding in Adult Inpatients with COVID-19 in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chronological Changes of Viral Shedding in Adult Inpatients with COVID-19 in Wuhan, China
Creator	Li, Yan Yang, Jie Li, Dong Zhu, Cheng-Liang Tong, Yong-Qing Feng, Li-Na Huang, Jing-Tao Liu, Ming-Jun Liu, Song-Mei Lv, Zhi-Hua Qiu, Shi-Li Ran, Chen-Yang Ran, Ruo-Xi Su, Han-Wen Xiao, Meng-Yao Yang, Yu-Ting
Source	Medline; PMC
abstract	BACKGROUND: In December 2019, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan. Epidemiological and clinical characteristics of patients with COVID-19 have been reported, but the relationships between laboratory features and viral load has not been comprehensively described. METHODS: Adult inpatients (≥18 years old) with COVID-19 who underwent multiple (≥ 5 times) nucleic acid tests with nasal and pharyngeal swabs were recruited from Renmin Hospital of Wuhan University, including general patients (n=70), severe patients (n=195) and critical patients (n=43). Laboratory data, demographic and clinical data were extracted from electronic medical records. The fitted polynomial curve was used to explore the association between serial viral loads and illness severity. RESULTS: Viral load of SARS-CoV-2 peaked within the first few days (2-4 days) after admission, then decreased rapidly along with virus rebound under treatment. Critical patients had the highest viral loads, in contrast to the general patients showing the lowest viral loads. The viral loads were higher in sputum compared with nasal and pharyngeal swab (p=0.026). The positive rate of respiratory tract samples was significantly higher than that of gastrointestinal tract samples (p<0.001). The SARS-CoV-2 viral load was negatively correlated with portion parameters of blood routine and lymphocyte subsets, and was positively associated with laboratory features of cardiovascular system. CONCLUSIONS: The serial viral loads of patients revealed whole viral shedding during hospitalization and the resurgence of virus during the treatment, which could be used for early warning of illness severity, thus improve antiviral interventions.
has issue date	2020-05-23(xsd:dateTime)
bibo:doi	10.1093/cid/ciaa631
bibo:pmid	32445580
has license	no-cc
sha1sum (hex)	a388bb0f505ada63f9e25ceecd3da44038f626a7
schema:url	https://doi.org/10.1093/cid/ciaa631
resource representing a document's title	Chronological Changes of Viral Shedding in Adult Inpatients with COVID-19 in Wuhan, China
has PubMed Central identifier	PMC7314240
has PubMed identifier	32445580
schema:publication	Clin Infect Dis
resource representing a document's body	covid:a388bb0f505ada63f9e25ceecd3da44038f626a7#body_text
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