About: Molecular study of porcine transmissible gastroenteritis virus after serial animal passages revealed point mutations in S protein

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About: Molecular study of porcine transmissible gastroenteritis virus after serial animal passages revealed point mutations in S protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular study of porcine transmissible gastroenteritis virus after serial animal passages revealed point mutations in S protein
Creator	Buesa, Javier Baybikov, Taufik Abid, Salem Andreeva, Olga Aouni, Mahjoub Ben, Nabil Bjadovskaya, Olga Chupin, Sergei Prokhvatilova, Larisa
Source	Medline; PMC
abstract	Porcine respiratory coronavirus is related genetically to porcine transmissible gastroenteritis virus with a large deletion in S protein. The respiratory virus is a mutated form that may be a consequence of the gastroenteritis virus’s evolution. Intensive passages of the virus in its natural host may enhance the appearance of mutations and therefore may contribute to any attenuated form of the virus. The objective of this study was to characterize the porcine transmissible gastroenteritis virus TMK22 strain after passages in piglets from 1992 until 2007. A typical experimental infection, molecular characterization, and serological analysis were also carried out to further characterize and to evaluate any significant difference between strains. The sequence analysis showed two amino acid deletions and loss of an N-glycosylation site in transmissible gastroenteritis virus S protein after passages in piglets. Although these deletions were positioned at the beginning of the antigenic site B of S protein, no clinical differences were observed in piglets infected experimentally either with the native virus or the mutated one. Serological tests did not show any antibody reactivity difference between the two strains. In this article, we report that the S protein deletion did not affect the virus’s pathogenicity. The variety of the virus’s evolutionary forms may be a result, not only of the multiple passages in natural hosts, but also of other factors, such as different pathogens co-infection, nutrition, immunity, and others. Further studies need to be carried out to characterize the mutated strain.
has issue date	2010-12-28(xsd:dateTime)
bibo:doi	10.1007/s11262-010-0562-8
bibo:pmid	21188626
has license	no-cc
sha1sum (hex)	a3cd2546a8af56c9c648c9d11196a3871628c86e
schema:url	https://doi.org/10.1007/s11262-010-0562-8
resource representing a document's title	Molecular study of porcine transmissible gastroenteritis virus after serial animal passages revealed point mutations in S protein
has PubMed Central identifier	PMC7089490
has PubMed identifier	21188626
schema:publication	Virus Genes
resource representing a document's body	covid:a3cd2546a8af56c9c648c9d11196a3871628c86e#body_text
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