About: Evaluating MERS-CoV Entry Pathways

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluating MERS-CoV Entry Pathways
Creator	Gallagher, Tom Qing, Enya Hantak, Michael Galpalli, Gautami
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic pathogen with a broad host range. The extent of MERS-CoV in nature can be traced to its adaptable cell entry steps. The virus can bind host-cell carbohydrates as well as proteinaceous receptors. Following receptor interaction, the virus can utilize diverse host proteases for cleavage activation of virus-host cell membrane fusion and subsequent genome delivery. The fusion and genome delivery steps can be completed at variable times and places, either at or near cell surfaces or deep within endosomes. Investigators focusing on the CoVs have developed several methodologies that effectively distinguish these different cell entry pathways. Here we describe these methods, highlighting virus-cell entry factors, entry inhibitors, and viral determinants that specify the cell entry routes. While the specific methods described herein were utilized to reveal MERS-CoV entry pathways, they are equally suited for other CoVs, as well as other protease-dependent viral species.
has issue date	2019-09-14(xsd:dateTime)
bibo:doi	10.1007/978-1-0716-0211-9_2
bibo:pmid	31883084
has license	no-cc
sha1sum (hex)	a40ad0d8461ad96b5694a122c24c3129126c11c0
schema:url	https://doi.org/10.1007/978-1-0716-0211-9_2
resource representing a document's title	Evaluating MERS-CoV Entry Pathways
has PubMed Central identifier	PMC7121971
has PubMed identifier	31883084
schema:publication	MERS Coronavirus
resource representing a document's body	covid:a40ad0d8461ad96b5694a122c24c3129126c11c0#body_text
is schema:about of	named entity 'MERS-CoV' named entity 'steps' named entity 'viral' named entity 'nature' named entity 'PATHWAYS' named entity 'PROTEASE' named entity 'EITHER' named entity 'SPECIES' named entity 'THESE' named entity 'GENOME' named entity 'HOST CELL MEMBRANE' named entity 'ZOONOTIC PATHOGEN' named entity 'PATHWAYS' named entity 'SURFACES' named entity 'BIND' named entity 'METHODS' named entity 'TRACED' named entity 'SPECIFIC' named entity 'DEEP' named entity 'VIRUS' named entity 'BROAD' named entity 'EXTENT OF' named entity 'MERS-COV' named entity 'EVALUATING' named entity 'STEPS' named entity 'ACTIVATION' named entity 'HIGHLIGHTING' named entity 'PROTEASES' named entity 'PROTEINACEOUS' named entity 'SPECIFY' named entity 'DESCRIBED' named entity 'MEMBRANE FUSION' named entity 'REVEAL' named entity 'CHAPTER' named entity 'DIVERSE' named entity 'VARIABLE' named entity 'FOCUSING' named entity 'RECEPTORS' named entity 'NEAR' named entity 'CELL' named entity 'FOLLOWING' named entity 'DIFFERENT' named entity 'TIMES' named entity 'DEPENDENT' named entity 'ENTRY INHIBITORS' named entity 'PLACES' named entity 'HOST' named entity 'CARBOHYDRATES' named entity 'METHODOLOGIES' named entity 'ROUTES' named entity 'FUSION' named entity 'INVESTIGATORS' named entity 'COMPLETED' named entity 'COVS' named entity 'HOST RANGE' named entity 'VIRAL' named entity 'SUBSEQUENT' named entity 'CLEAVAGE' named entity 'ENTRY' named entity 'DESCRIBE' named entity 'ITS' named entity 'DETERMINANTS' named entity 'DELIVERY' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'NATURE' named entity 'ENDOSOMES' named entity 'HAVE' named entity 'HERE' named entity 'ENTRY' named entity 'ADAPTABLE' named entity 'equally' named entity 'proteinaceous' named entity 'bind' named entity 'deep' named entity 'describe' named entity 'suited' named entity 'pathogen' named entity 'proteases'

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