About: Activity of sputum p38 MAPK is correlated with airway inflammation and reduced FEV(1) in COPD patients

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About: Activity of sputum p38 MAPK is correlated with airway inflammation and reduced FEV(1) in COPD patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activity of sputum p38 MAPK is correlated with airway inflammation and reduced FEV(1) in COPD patients
Creator	Gao, Hui Huang, Cuiping Xie, Moying Ab, Huang Cuiping, Abcdefg Xinhua, B
Source	PMC
abstract	BACKGROUND: Inflammation and remodeling of the small airways are major determinants of the progression and severity of COPD. The present study explored the correlation between sputum p38 mitogen-activated protein kinase (MAPK) activity and airway inflammation and reduction of lung function in the patients with chronic obstructive pulmonary disease (COPD). MATERIAL/METHODS: Sputum samples were collected from 48 COPD patients and 12 healthy persons. Sputum p38 MAPK activity was measured by Western blotting and sputum levels of CXCL8 and neutrophil, and lung function was measured. The correlation between p38MAPK activity and airway inflammation and reduction of lung function was analyzed. RESULT: Our results showed the significantly increased expression of phospho-p38 MAPK and CXCL8 in the sputum samples of the COPD patients. The p38 MAPK activity was remarkably correlated with the CXCL8 level and neutrophils infiltration in the airway, and the decline of lung function in the COPD patients. CONCLUSIONS: These findings suggest the pivotal role of p38 MAPK in the airway inflammation of COPD patients. We propose p38 MAPK as a potential target for the treatment of COPD.
has issue date	2013-12-31(xsd:dateTime)
bibo:doi	10.12659/msm.889880
bibo:pmid	24382347
has license	no-cc
sha1sum (hex)	a410689981eddf53ed0073a2310941bb37913ab9
schema:url	https://doi.org/10.12659/msm.889880
resource representing a document's title	Activity of sputum p38 MAPK is correlated with airway inflammation and reduced FEV(1) in COPD patients
has PubMed Central identifier	PMC3890402
has PubMed identifier	24382347
schema:publication	Med Sci Monit
resource representing a document's body	covid:a410689981eddf53ed0073a2310941bb37913ab9#body_text
is schema:about of	named entity 'COPD' named entity 'REDUCED' named entity 'Activity' named entity 'CORRELATION' named entity 'PATIENTS' named entity 'PATIENTS' named entity 'REDUCTION' named entity 'MAJOR' named entity 'ACTIVITY' named entity 'CORRELATED' named entity 'ACTIVITY' named entity 'SPUTUM' named entity 'FEV 1' named entity 'PROGRESSION' named entity 'P38 MAPK' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'P38 MITOGEN-ACTIVATED PROTEIN KINASE' named entity 'SEVERITY' named entity 'DETERMINANTS' named entity 'SPUTUM' named entity 'LUNG FUNCTION' named entity 'REMODELING' named entity 'STUDY' named entity 'COPD' named entity 'SMALL AIRWAYS' named entity 'PRESENT' named entity 'INFLAMMATION' named entity 'AIRWAY INFLAMMATION' named entity 'AIRWAY INFLAMMATION' covid:arg/a410689981eddf53ed0073a2310941bb37913ab9 named entity 'P<0.01' named entity 'p38 MAPK' named entity 'p38 MAPK' named entity 'sputum' named entity 'COPD' named entity 'protein' named entity 'sulfate' named entity 'sputum' named entity 'COPD' named entity 'inflammation' named entity 'CXCL8' named entity 'FEV' named entity 'CXCL8' named entity 'neutrophils' named entity 'p38' named entity 'pathogenesis' named entity 'Protein' named entity 'CXCL8' named entity 'tumor necrosis factor' named entity 'CXCL8' named entity 'serum' named entity 'NF-kB' named entity 'neutrophils' named entity 'FEV' named entity 'CXCL8' named entity 'MMPs' named entity 'mRNA' named entity 'CXCL8' named entity 'phosphorylated' named entity 'CXCL8' named entity 'p38 MAPK' named entity 'infection' named entity 'thyrotoxicosis' named entity 'asthma' named entity 'PCR' named entity 'sputum' named entity 'saline' named entity 'neutrophils' named entity 'chemotaxis' named entity 'neutrophils' named entity 'forced expiratory volume' named entity 'actin' named entity 'MAPK kinase' named entity 'sputum' named entity 'sputum' named entity 'pathogenesis'

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