About: Prognosis of nonspecific interstitial pneumonia correlates with perivascular CD4+ T lymphocyte infiltration of the lung

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About: Prognosis of nonspecific interstitial pneumonia correlates with perivascular CD4+ T lymphocyte infiltration of the lung Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Prognosis of nonspecific interstitial pneumonia correlates with perivascular CD4+ T lymphocyte infiltration of the lung
Creator	Qin, Ling Xiao, Yi Liu, Hongrui Qin, Mingwei Wang, Wenze Zheng, Wenjie Shi, Juhong
source	PMC
abstract	BACKGROUND: Nonspecific interstitial pneumonia (NSIP) is characterized by interstitial infiltration of T lymphocytes, and subpopulations of these cells may be associated with the progression of fibrosis. However, few studies evaluate the correlation of prognosis with this characteristic. Therefore, we performed morphological and quantitative analyses of T lymphocytes in patients with NSIP and evaluated the relationship between T lymphocytes and prognosis. METHODS: Immunohistochemistry was used to detect the presence of CD4+ and CD8+ T lymphocytes in 55 biopsies of patients with NSIP to determine the numbers of these T cell subpopulations in lymphoid follicles as well as in perivascular, interstitial, and peribronchial anatomical compartments. The relationship between CD4+ and CD8+ T lymphocyte populations and prognosis was analyzed. RESULTS: The mean age of 55 patients was 48.9 ± 10.5 years, and 36 (65 %) of patients were women. All patients were followed for a mean duration of 46 ± 25 months. Thirteen (23.6 %) patients died during follow-up. Perivascular CD4+ lymphocyte infiltration (HR, 0.939; 95 % CI, 0.883–0.999; p = 0.048) was an independent risk factor for survival. Perivascular infiltrates of CD4+ T lymphocytes correlated with survival time (r = 0.270, p = 0.046). Patients with improved forced vital capacity survived longer and had higher numbers of CD4+ T lymphocytes that infiltrated perivascular tissue. The densities of CD4+ and CD8+ T lymphocytes infiltrating other tissues were not significantly associated with survival time. CONCLUSIONS: Perivascular infiltration of CD4+ T lymphocytes in patients with NSIP correlated with prognosis. The underlying mechanisms are unknown and require further studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0122-z) contains supplementary material, which is available to authorized users.
has issue date	2015-10-24(xsd:dateTime)
bibo:doi	10.1186/s12890-015-0122-z
bibo:pmid	26496721
has license	cc-by
sha1sum (hex)	a46d2cd0e65ba71e9d1ccf20762c9043ed3e67c2
schema:url	https://doi.org/10.1186/s12890-015-0122-z
resource representing a document's title	Prognosis of nonspecific interstitial pneumonia correlates with perivascular CD4+ T lymphocyte infiltration of the lung
has PubMed Central identifier	PMC4619990
has PubMed identifier	26496721
schema:publication	BMC Pulm Med
resource representing a document's body	covid:a46d2cd0e65ba71e9d1ccf20762c9043ed3e67c2#body_text
is schema:about of	named entity 'PERIVASCULAR' named entity 'PROGNOSIS' named entity 'CD4' named entity 'EVALUATE' named entity 'CHARACTERISTIC' named entity 'PROGNOSIS' named entity 'MORPHOLOGICAL' named entity 'RELATIONSHIP' named entity 'LUNG' named entity 'PATIENTS' named entity 'PROGRESSION' named entity 'LYMPHOCYTE INFILTRATION' named entity 'CHARACTERIZED' named entity 'T LYMPHOCYTES' named entity 'FIBROSIS' named entity 'STUDIES' named entity 'PERFORMED' named entity 'THESE' named entity 'BACKGROUND' named entity 'NONSPECIFIC INTERSTITIAL PNEUMONIA' named entity 'MAY BE' named entity 'QUANTITATIVE' named entity 'NSIP' named entity 'INTERSTITIAL INFILTRATION' named entity 'CELLS' named entity 'T LYMPHOCYTE' named entity 'CORRELATION' named entity 'NONSPECIFIC INTERSTITIAL PNEUMONIA' named entity 'ASSOCIATED WITH' covid:arg/a46d2cd0e65ba71e9d1ccf20762c9043ed3e67c2 named entity 'evaluated' named entity 'prognosis' named entity 'prognosis' named entity 'Nonspecific interstitial pneumonia' named entity 'lymphocytes' named entity 'Prognosis' named entity 'anatomical' named entity 'CD4+ T lymphocytes' named entity 'CD4+ T lymphocytes' named entity 'Cyclophosphamide' named entity 'reticular opacity' named entity 'FVC' named entity 'Complete blood count' named entity 'CTD' named entity 'Immunohistochemical' named entity 'CD4+ T cells' named entity 'DLCO' named entity 'histologic' named entity 'fibrotic' named entity 'follow-up' named entity 'CD4 cells' named entity 'wheeze' named entity 'polymyositis' named entity 'CD4+' named entity 'follicle' named entity 'perivascular' named entity 'Small blood vessels' named entity 'perivascular' named entity 'pulmonary function' named entity 'animal model' named entity 'GGO' named entity 'perivascular' named entity 'IPF' named entity 'Clinical features' named entity 'CD4+ T lymphocytes' named entity 'FVC' named entity 'CD4+ T lymphocytes' named entity 'interstitial pneumonitis' named entity 'probability' named entity 'FVC' named entity 'PUMCH' named entity 'Tris-Buffered Saline' named entity 'smokers' named entity 'perivascular' named entity 'CD8'

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