About: Structural characterization and immunomodulating activities of a novel polysaccharide from Nervilia fordii

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About: Structural characterization and immunomodulating activities of a novel polysaccharide from Nervilia fordii Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural characterization and immunomodulating activities of a novel polysaccharide from Nervilia fordii
Creator	Jiao, Yang Luo, Di Luo, Xuan Qiu, Li Wei, Qian Wu, Yunqiu Xie, Jizhao Zou, Luhui
topic	covid:a4d212888800a6a94e55b99670b95f08dc8029de#this
Source	Elsevier; Medline; PMC
abstract	Abstract Nervilia fordii (Hance) Schltr. has been widely used as a medicinal and edible herb in Southwest China and Southeast Asia. In this study, NFP-1, a new water-soluble polysaccharidewith a purity of 97.8%, was purified from water extract of Nervilia fordii by DEAE-cellulose and Sephadex G-100 chromatography. NFP-1 has a relative molecular weight of 950 kDa determined by high performance gel-permeation chromatography (HPGPC). Its monosaccharide compositions were analyzed by high performance liquid chromatography (HPLC) after pre-column derivatizing its hydrolysate with 1-phenyl-3-methyl-5-pyrazolone (PMP). NFP-1 mainly consists of galactose, arabinose, rhamnose, and galacturonic acid. Based on FT-IR, methylation and GC–MS analysis, and NMR, the structure unit of NFP-1 was established as →4)-α-Rhap-(2→ 4)-α-GalpA-(1→2)-α-Rhap-(1→2)-α-Rhap-(4→1)-β-Galp-T containing two branch chains of →2,4)-α-Rhap-(1→5)-α-Araf-(1→3)-α-Araf-(1→, and →2,4)-α-Rhap-(1→4)-β-Galp-(1→. The immunomodulatory assays revealed the dual-functionalities of NFP-1. NFP-1 could significantly induce the secretion of nitric oxide (NO), and promote the secretions of TNF-α, IL-6, and IL-1β in RAW264.7 macrophages. NFP-1 could also significantly inhibit the production of NO, depress the secretions of TNF-α, IL-6 and IL-1β in RAW264.7 macrophages activated by lipopolysaccharide (LPS), and promote the production of IL-10 meanwhile. Our study suggested that Nervilia fordii could be an ideal medicinal or functional food due to its dual immunomodulatory activities.
has issue date	2018-07-15(xsd:dateTime)
bibo:doi	10.1016/j.ijbiomac.2018.03.124
bibo:pmid	29578012
has license	els-covid
sha1sum (hex)	a4d212888800a6a94e55b99670b95f08dc8029de
schema:url	https://doi.org/10.1016/j.ijbiomac.2018.03.124
resource representing a document's title	Structural characterization and immunomodulating activities of a novel polysaccharide from Nervilia fordii
has PubMed Central identifier	PMC7112443
has PubMed identifier	29578012
schema:publication	International Journal of Biological Macromolecules
resource representing a document's body	covid:a4d212888800a6a94e55b99670b95f08dc8029de#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/a4d212888800a6a94e55b99670b95f08dc8029de
is schema:about of	named entity 'NFP' named entity 'macrophages' named entity 'inhibit' named entity 'relative' named entity 'NFP' named entity 'unit' named entity 'high' named entity 'polysaccharide' named entity 'TNF-' named entity 'ESTABLISHED' named entity '924' named entity '100' named entity 'CHINA' named entity 'GEL-PERMEATION CHROMATOGRAPHY' named entity 'ACTIVATED' named entity 'IL-10' named entity 'EDIBLE' named entity 'SECRETIONS' named entity 'ANALYSIS' named entity 'UNIT' named entity 'IDEAL' named entity 'SEPHADEX' named entity 'NERVILIA FORDII' named entity '921' named entity 'ARABINOSE' named entity 'DUAL' named entity 'DUE TO' named entity 'OUR' named entity 'IL-6' named entity 'NOVEL' named entity 'HIGH' named entity 'PRE' named entity 'IMMUNOMODULATORY' named entity 'STUDY' named entity 'WATER' named entity 'RHAMNOSE' named entity 'POLYSACCHARIDE' named entity 'ACTIVITIES' named entity 'NERVILIA FORDII' named entity 'GALACTURONIC ACID' named entity 'NITRIC OXIDE' named entity 'FUNCTIONAL FOOD' named entity 'PHENYL' named entity 'KDA' named entity 'PRODUCTION' named entity 'MACROPHAGES' named entity '925' named entity 'USED' named entity '950' named entity 'BASED' named entity 'EXTRACT' named entity 'PERFORMANCE' named entity 'RELATIVE' named entity 'COULD BE' named entity 'INDUCE' named entity 'NMR' named entity 'DETERMINED BY' named entity 'SOUTHWEST' named entity '282' named entity 'RAW264.7' named entity 'PROMOTE' named entity '923' named entity 'CONTAINING' named entity 'COMPOSITIONS' named entity 'SECRETION' named entity 'METHYL' named entity 'NEW WATER' named entity 'HERB' named entity 'ARAF' named entity '922' named entity 'CHAINS' named entity 'DEAE-CELLULOSE'

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