About: First Discovery and Stucture-Activity Relationship Study of Phenanthroquinolizidines as Novel Antiviral Agents against Tobacco Mosaic Virus (TMV)

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About: First Discovery and Stucture-Activity Relationship Study of Phenanthroquinolizidines as Novel Antiviral Agents against Tobacco Mosaic Virus (TMV) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	First Discovery and Stucture-Activity Relationship Study of Phenanthroquinolizidines as Novel Antiviral Agents against Tobacco Mosaic Virus (TMV)
Creator	Cui, Mingbo Feng, Anzheng Liu, Yuxiu Wang, Lizhong Wang, Qingmin Wang, Ziwen
source	PMC
abstract	A series of phenanthroquinolizidine alkaloids 1–24 were prepared and first evaluated for their antiviral activity against tobacco mosaic virus (TMV). The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1, 2, 15 and 16 displayed significantly higher activity than (R)-antofine and commercial Ningnanmycin at the same test condition. The substituents on the phenanthrene moiety play an important role for maintaining high in vivo antiviral activity. The introduction of 6-hydroxyl, which is proposed to interact with TMV RNA, did increased anti-TMV activity. The 14aR-configuration was confirmed to be the preferred antiviral configuration for phenanthroquinolizidine alkaloids. Introduction of hydroxy group at 15-position of phenanthroquinolizidine alkaloids increased activity for S-configuration but decreased activity for R-configuration. Present study provides fundamental support for development and optimization of phenanthroquinolizidine alkaloids as potential inhibitors of plant virus.
has issue date	2012-12-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0052933
bibo:pmid	23285230
has license	cc-by
sha1sum (hex)	a4ffcadecc4b60c30df8f699c480724523272e62
schema:url	https://doi.org/10.1371/journal.pone.0052933
resource representing a document's title	First Discovery and Stucture-Activity Relationship Study of Phenanthroquinolizidines as Novel Antiviral Agents against Tobacco Mosaic Virus (TMV)
has PubMed Central identifier	PMC3532156
has PubMed identifier	23285230
schema:publication	PLoS One
resource representing a document's body	covid:a4ffcadecc4b60c30df8f699c480724523272e62#body_text
is schema:about of	named entity 'evaluated' named entity 'moiety' named entity 'Novel' named entity 'STUDY' named entity 'ANTIVIRAL AGENTS' named entity 'RESULTS' named entity 'HIGHER' named entity 'PHENANTHRENE' named entity 'ALKALOIDS' named entity 'NINGNANMYCIN' named entity 'EVALUATED' named entity 'TMV' named entity 'COMMERCIAL' named entity 'MAINTAINING' named entity 'CONDITION' named entity 'IN VIVO' named entity 'THESE' named entity 'EXCELLENT' covid:arg/a4ffcadecc4b60c30df8f699c480724523272e62 named entity 'ANTIVIRAL ACTIVITY' named entity 'HIGH' named entity 'PHENANTHROQUINOLIZIDINE' named entity 'TEST' named entity 'DISPLAYED' named entity 'ACTIVITY' named entity 'NOVEL' named entity 'RELATIONSHIP' named entity 'ROLE' named entity 'MOIETY' named entity 'MOST OF' named entity 'ACTIVITY' named entity 'DISCOVERY' named entity 'TOBACCO MOSAIC VIRUS' named entity 'ANTOFINE' named entity 'TOBACCO MOSAIC VIRUS' named entity 'SERIES' named entity 'PLAY' named entity 'BIOASSAY' named entity 'PREPARED' named entity 'IMPORTANT' named entity 'GOOD' named entity 'THEIR' named entity 'antiviral' named entity 'tobacco mosaic virus' named entity 'activity' named entity 'hexane' named entity 'antiviral activity' named entity 'racemic' named entity 'NMR spectra' named entity '1:2' named entity 'antiviral activity' named entity 'TMV' named entity 'agrochemicals' named entity 'plant virus' named entity 'alkaloids' named entity 'lesion' named entity 'activity' named entity 'vivo' named entity 'alkaloids' named entity 'antiviral activity' named entity 'Antiviral Agents' named entity 'Alkaloids' named entity 'Ribavirin' named entity 'NaOH' named entity 'hydrogen' named entity 'antiviral activity' named entity 'mmol' named entity 'trifluoroacetic acid' named entity 'Natural product' named entity 'antiviral activity' named entity 'antiviral activity' named entity 'antiviral activity' named entity 'EtOAc' named entity 'silica gel' named entity 'methyl' named entity 'TMV'

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