About: Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia in Kunming

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia in Kunming
Creator	Xu, Bing Tang, Xiaoqing Shen, Jie Li, Xiang Fu, Haiyan Li, Hongjuan Luo, Yu Zhou, Yujun
topic	covid:a5039336577ac0fed15b784adb912df2a6a143f3#this
Source	MedRxiv
abstract	Objective: To analyze the clinical characteristics of patients with novel coronavirus pneumonia in Kunming City, and to study the correlation between nutritional status and immune function. Methods: Clinical data of 36 patients with novel coronavirus pneumonia in isolation area of Kunming Third People's Hospital from January 31 to February 15, 2020 were collected, and the basic situation, clinical characteristics, laboratory examination and CT imaging characteristics were analyzed. Serum albumin (ALB), prealbumin (PAB), hypersensitive c-reactive protein (hs-crp), CD3T cells, CD4T cells, CD8T cells and normal control group were analyzed. A simple linear regression analysis of the relationship between proalbumin and T cell subpopulation counts in the blood of patients. Results: (1) The patients with new coronavirus pneumonia in Kunming were mainly of common type. (2) 50% of the patients' first symptoms were fever and cough; (3) The total number of white blood cells in peripheral blood was normal or decreased in 23 cases (79%), and the lymphocyte count decreased in 5 cases (13.89%), without anemia. Hypersensitive c-reactive protein increased in 19 (52.78%) cases, and procalcitonin increased in 1 case. Albumin decreased in 5 cases (13.89%), proalbumin decreased in 15 cases (41.67%), alanine transaminase increased slightly in 4 cases (11.11%), alanine transaminase increased slightly in 4 cases (11.11%), total bilirubin increased slightly in 11 cases (30.56%), and renal function and blood coagulation were normal. Absolute value of CD3+T cells is with a decrease in 21 cases (58.3%), CD4+T in 28 cases (77.8%), CD8+T in 17 cases (47.2%), and CD4+/ CD8+ inverse in 6 cases (16.7%). (4) The prealbumin, CD3 T cells, CD4 T cells and CD8 T cells in the new coronavirus pneumonia group were significantly lower than those in the normal control group, and the hypersensitive c-reactive protein was higher than that in the normal control group. (5) The levels of PAB in the serum of the patients were linearly correlated with hs-crp, CD3 T cells, CD4 T cells and CD8 T cells, and the correlation coefficients were -0.474, 0.558, 0.467 and 0.613, respectively, showing statistical differences. Conclusion: The clinical characteristics of the novel coronavirus pneumonia in Kunming are different from those in Wuhan. The changes of serum proalbumin and T cell subsets are relatively obvious. Changes in serum proalbumin may contribute to the early warning of novel coronavirus pneumonia. The nutritional status of patients with common and mild pneumonia should be considered.
has issue date	2020-03-01(xsd:dateTime)
bibo:doi	10.1101/2020.02.28.20029173
has license	medrxiv
sha1sum (hex)	a5039336577ac0fed15b784adb912df2a6a143f3
schema:url	https://doi.org/10.1101/2020.02.28.20029173
resource representing a document's title	Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia in Kunming
resource representing a document's body	covid:a5039336577ac0fed15b784adb912df2a6a143f3#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/a5039336577ac0fed15b784adb912df2a6a143f3
is schema:about of	named entity 'Clinical' named entity 'cells' named entity 'Novel' covid:arg/a5039336577ac0fed15b784adb912df2a6a143f3 named entity 'Hospital' named entity 'PAB' named entity 'isolation' named entity 'preprint' named entity 'Hubei' named entity 'immune function' named entity 'laboratory' named entity 'pneumonia' named entity 'study' named entity 'crp' named entity 'clinical characteristics' named entity 'immune function' named entity 'Serum albumin' named entity 'Kunming' named entity 'pneumonia' named entity 'simple linear regression' named entity 'Clinical Characteristics' named entity 'epidemiology' named entity 'normal distribution' named entity 'preprint' named entity 'prealbumin' named entity 'preprint' named entity 'CC-BY-ND' named entity 'prealbumin' named entity 'fever' named entity 'CD3' named entity 'control group' named entity 'fever' named entity 'normal distribution' named entity 'coronavirus' named entity 'prealbumin' named entity 'preprint' named entity 'half-life' named entity 'condition monitoring' named entity 'χ2 test' named entity 'preprint' named entity 'malnutrition' named entity 'coronavirus' named entity 'inflammation' named entity 'severe pneumonia' named entity 'immunoglobulin' named entity 'hormone' named entity 'medRxiv' named entity 'coronavirus infection' named entity 'doi' named entity 'doi' named entity 'Tongji Hospital' named entity 'prealbumin' named entity 'nutritional status' named entity 'doi' named entity 'medRxiv' named entity 'medRxiv' named entity 'preprint' named entity 'hypoalbuminemia' named entity 'CC-BY-ND' named entity 'Hubei Province' named entity 'written consent' named entity 'diagnostic criteria' named entity 'CD8 +' named entity 'medRxiv' named entity 'preprint' named entity 'simple linear regression' named entity 'Simple linear regression' named entity 'Wuhan' named entity 'half-life' named entity 'immune function' named entity 'preprint' named entity 'c-reactive protein' named entity 'fever' named entity 'clinical characteristics' named entity 'tumor' named entity 'coronavirus infection'

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