About: Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

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About: Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza
Creator	Zheng, Bo-Jian Yuen, Kwok-Yung Wang, Dong Zhou, Jie Chen, Yu Chu, Hin Yang, Dong Li, Lanjuan Zheng, Shufa Li, Cun Bossé, Yohan Brandsma, Corry-Anke Cheng, Zhongshan Hao, Ke Song, You-Qiang To, Kai-Wang En Obeidat, Ma
Source	Medline; PMC
abstract	The genetic predisposition to severe A(H1N1)2009 (A[H1N1]pdm09) influenza was evaluated in 409 patients, including 162 cases with severe infection and 247 controls with mild infection. We prioritized candidate variants based on the result of a pilot genome-wide association study and a lung expression quantitative trait locus data set. The GG genotype of rs2070788, a higher-expression variant of TMPRSS2, was a risk variant (odds ratio, 2.11; 95% confidence interval, 1.18–3.77; P = .01) to severe A(H1N1)pdm09 influenza. A potentially functional single-nucleotide polymorphism, rs383510, accommodated in a putative regulatory region was identified to tag rs2070788. Luciferase assay results showed the putative regulatory region was a functional element, in which rs383510 regulated TMPRSS2 expression in a genotype-specific manner. Notably, rs2070788 and rs383510 were significantly associated with the susceptibility to A(H7N9) influenza in 102 patients with A(H7N9) influenza and 106 healthy controls. Therefore, we demonstrate that genetic variants with higher TMPRSS2 expression confer higher risk to severe A(H1N1)pdm09 influenza. The same variants also increase susceptibility to human A(H7N9) influenza.
has issue date	2015-10-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jiv246
bibo:pmid	25904605
has license	no-cc
sha1sum (hex)	a51b5561a16889a18c75e7ce907be745c173ffea
schema:url	https://doi.org/10.1093/infdis/jiv246
resource representing a document's title	Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza
has PubMed Central identifier	PMC7107393
has PubMed identifier	25904605
schema:publication	J Infect Dis
resource representing a document's body	covid:a51b5561a16889a18c75e7ce907be745c173ffea#body_text
is schema:about of	named entity 'single-nucleotide polymorphism' named entity 'severe' named entity 'Luciferase' named entity 'expression' named entity 'tag' named entity 'controls' named entity 'INFLUENZA' named entity 'REGULATED' named entity 'TAG' named entity 'GENETIC' named entity 'SEVERE INFECTION' named entity 'RESULT' named entity 'EXPRESSION QUANTITATIVE TRAIT LOCUS' named entity 'HUMAN' covid:arg/a51b5561a16889a18c75e7ce907be745c173ffea named entity 'ELEMENT' named entity 'CANDIDATE' named entity '102' named entity 'INCREASE' named entity 'EXPRESSION' named entity 'SEVERE' named entity 'DATA SET' named entity 'PATIENTS' named entity 'RESULTS' named entity 'INFECTION' named entity 'INFLUENZA' named entity 'RATIO' named entity 'CASES' named entity 'GENETIC PREDISPOSITION' named entity 'VARIANTS' named entity 'IDENTIFICATION' named entity 'SPECIFIC' named entity 'CONFIDENCE INTERVAL' named entity 'SINGLE-NUCLEOTIDE POLYMORPHISM' named entity 'GENOTYPE' named entity 'FUNCTIONAL' named entity 'REGULATORY REGION ' named entity '162' named entity 'SUSCEPTIBILITY' named entity 'RISK' named entity 'SUSCEPTIBILITY GENE' named entity 'SEVERE' named entity 'PANDEMIC' named entity 'WAS A' named entity 'GENOME-WIDE ASSOCIATION STUDY' named entity 'EVALUATED' named entity 'ASSOCIATED WITH' named entity 'HEALTHY' named entity 'MILD' named entity 'INCLUDING' named entity '28A' named entity 'TMPRSS2' named entity 'LUNG' named entity 'IDENTIFIED' named entity 'VARIANT' named entity 'BASED' named entity 'PILOT' named entity 'HIGHER' named entity 'TMPRSS2' named entity 'LUCIFERASE ASSAY' named entity 'severe' named entity 'genome-wide association study' named entity 'infection' named entity 'patients' named entity 'evaluated'

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