About: Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER
Creator	Lippincott-Schwartz, Jennifer Bonifacino, Juan Klausner, Richard Yuan, Lydia
source	Elsevier; Medline; PMC
abstract	Abstract In cells treated with brefeldin A (BFA), movement of newly synthesized membrane proteins from the endoplasmic reticulum (ER) to the Golgi apparatus was blocked. Surprisingly, the glycoproteins retained in the ER were rapidly processed by cis/medial Golgi enzymes but not by trans Golgi enzymes. An explanation for these observations was provided from morphological studies at both the light and electron microscopic levels using markers for the cis/medial and trans Golgi. They revealed a rapid and dramatic redistribution to the ER of components of the cis/medial but not the trans Golgi in response to treatment with BFA. Upon removal of BFA, the morphology of the Golgi apparatus was rapidly reestablished and proteins normally transported out of the ER were efficiently and rapidly sorted to their final destinations. These results suggest that BFA disrupts a dynamic membrane-recycling pathway between the ER and cis/medial Golgi, effectively blocking membrane transport out of but not back to the ER.
has issue date	1989-03-10(xsd:dateTime)
bibo:doi	10.1016/0092-8674(89)90685-5
bibo:pmid	2647301
has license	els-covid
sha1sum (hex)	a581b86b06b3e62dae9b13aa9cc910119f9f6513
schema:url	https://doi.org/10.1016/0092-8674%2889%2990685-5
resource representing a document's title	Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER
has PubMed Central identifier	PMC7173269
has PubMed identifier	2647301
schema:publication	Cell
resource representing a document's body	covid:a581b86b06b3e62dae9b13aa9cc910119f9f6513#body_text
is schema:about of	named entity 'Golgi' named entity 'rough endoplasmic reticulum' named entity 'solubilized' named entity 'hybridoma' named entity 'organelles' named entity '2B4' named entity 'Golgi' named entity 'fluorescein' named entity 'transmembrane' named entity 'brefeldin A' named entity 'cycloheximide' named entity 'carbohydrate' named entity 'Golgi' named entity 'BFA' named entity 'glycoproteins' named entity 'immunofluorescence' named entity 'Golgi' named entity 'oligosaccharides' named entity 'BFA' named entity 'intracellular' named entity 'BFA' named entity 'oligosaccharide' named entity 'protein synthesis inhibitor' named entity 'neuraminidase' named entity 'BFA' named entity 'intracellular' named entity 'BFA' named entity 'cisternae' named entity 'Rockville, MD' named entity 'morphology' named entity 'Golgi' named entity 'Golgi' named entity 'repair mechanism' named entity 'BFA' named entity 'saponin' named entity 'vesicles' named entity 'mannosidase II' named entity 'antibodies' named entity 'lipid' named entity 'receptor' named entity 'endosome' named entity 'intracellular' named entity 'digestion' named entity 'solubilized' named entity 'NRK' named entity 'cell surface' named entity 'perinuclear structure' named entity 'Golgi' named entity 'Golgi' named entity 'endocytic pathway' named entity 'BFA' named entity 'sites of action' named entity 'cisternae' named entity 'organelle' named entity 'kinetics' named entity 'antibodies' named entity 'N-linked' named entity 'nucleus' named entity 'metabolically' named entity 'antibody' named entity 'BFA' named entity 'oligosaccharide' named entity 'coronaviruses' named entity 'cis' named entity 'antibodies' named entity 'Golgi' named entity 'BFA' named entity 'TCRs' named entity 'BFA' named entity 'mannosidase II' named entity 'Golgi apparatus' named entity 'Katy Perry' named entity 'BFA' named entity 'vesicular stomatitis virus' named entity 'cis' named entity 'BFA' named entity 'Golgi apparatus' named entity 'RBL cells'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software