About: Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus

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About: Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus
Creator	Wu, Jie Chen, Jiapei Cong, Yuwen Shan, Yajun Yuan, Xiaoling Zhao, Zhenhu Yao, Zhenyu Chen, Bo Yang, Zhen
Source	Elsevier; Medline; PMC
abstract	Abstract The open reading frame 3 (ORF3) of the severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes a predicted 154-amino acid protein, which lacks similarities to any known protein, and is named 3b. In this study, it was shown that 3b protein was predominately localized to nucleus with EGFP tag at its N- or C-terminus. The localization patterns were similar in different transfected cells. Immuno-fluorescence assay revealed that 3b protein was co-localized well with C23 in nucleolus. C23, B23 and fibrillarin all are important nucleolar proteins, which localize in the region of the nucleolus. Co-transfection of p3b-EGFP with pC23-DsRed, pB23-DsRed and pfibrillarin-DsRed further confirmed 3b's nucleolus localization. With construction of serial truncated mutants of 3b, a region (residues 134–154 aa) responsible for nucleolar localization was determinated in 3b protein. These results provide a new insight for further functional studies of SARS-CoV 3b protein.
has issue date	2005-12-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2005.06.001
bibo:pmid	16046244
has license	els-covid
sha1sum (hex)	a583ecec9dcf29b95129d180906f2466c1d1965a
schema:url	https://doi.org/10.1016/j.virusres.2005.06.001
resource representing a document's title	Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus
has PubMed Central identifier	PMC7114190
has PubMed identifier	16046244
schema:publication	Virus Research
resource representing a document's body	covid:a583ecec9dcf29b95129d180906f2466c1d1965a#body_text
is schema:about of	named entity 'SARS-CoV' named entity 'insight' named entity 'nucleolus' named entity 'fibrillarin' named entity 'similarities' named entity 'With' named entity 'protein' named entity 'NUCLEOLAR' named entity 'REVEALED' named entity 'OPEN READING FRAME' named entity 'SARS-COV' named entity 'CONSTRUCTION' named entity 'PREDOMINATELY' named entity 'PROVIDE' named entity 'DSRED' named entity 'EGFP' named entity 'GENOME' covid:arg/a583ecec9dcf29b95129d180906f2466c1d1965a named entity 'PROTEIN ' named entity 'RESPONSIBLE' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'LOCALIZED' named entity 'THESE' named entity 'PROTEIN' named entity 'CELLS' named entity 'KNOWN' named entity '134' named entity 'C-TERMINUS' named entity 'PATTERNS' named entity '154' named entity 'DIFFERENT' named entity 'EGFP TAG' named entity 'B23' named entity 'LOCALIZATION' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'A PROTEIN' named entity 'NUCLEUS' named entity 'SIMILAR' named entity 'STRUCTURAL PROTEIN' named entity 'ENCODED' named entity 'LACKS' named entity 'STUDIES' named entity 'NEW' named entity 'INSIGHT' named entity 'NAMED' named entity 'PROTEIN ' named entity 'MUTANTS' named entity 'NUCLEOLAR' named entity 'ACID' named entity 'FIBRILLARIN' named entity 'PROTEINS' named entity 'P3B' named entity 'TRUNCATED' named entity 'LOCALIZATION' named entity 'IMPORTANT' named entity 'ITS' named entity 'STUDY' named entity 'FUNCTIONAL' named entity 'REGION' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'CONFIRMED' named entity 'PREDICTED' named entity 'C23' named entity '27S' named entity 'NUCLEOLUS' named entity 'TRANSFECTION' named entity 'NON-' named entity 'SERIAL' named entity 'RESULTS' named entity 'tag' named entity 'EGFP' named entity 'transfected' named entity 'protein'

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