About: Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience

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About: Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience
Creator	Sun, Ying Wang, Fu-Sheng Chang, Christopher Dong, Com, Yanli Dong, Yanli Li, Baosen Wang, Lifeng Xie, Huan
Source	Elsevier; Medline; PMC
abstract	Abstract COVID-19 has become one of the worst infectious disease outbreaks of recent times, with over 2.1 million cases and 120,000 deaths so far. Our study investigated the demographic, clinical, laboratory and imaging features of 63 patients with COVID-19 in Beijing. Patients were classified into four groups, mild, moderate, severe and critically ill. The mean age of our patients was 47 years of age (range 3–85) and there was a slight male predominance (58.7%). Thirty percent of our patients had severe or critically ill disease, but only 20% of severe and 33% of critically ill patients had been to Wuhan. Fever was the most common presentation (84.1%), but cough was present in only slightly over half of the patients. We found that lymphocyte and eosinophils count were significantly decreased in patients with severe disease (p = 0.001 and p = 0.000, respectively). Eosinopenia was a feature of higher levels of severity. Peripheral CD4+, CD8+ T lymphocytes, and B lymphocytes were significantly decreased in severe and critically ill patients, but there was only a non-statistically significant downward trend in NK cell numbers with severity. Of note is that liver function test including AST, ALT, GGT and LDH were elevated, and albumin was decreased. The inflammatory markers CRP, ESR and ferritin were elevated in patients with severe disease or worse. IL-6 levels were also higher, indicating that the presence of a hyperimmune inflammatory state portends higher morbidity and mortality. In a binary logistic regression model, C-reactive protein level (OR 1.073, [CI, 1.013–1.136]; p = 0.017), CD8 T lymphocyte counts (OR 0.989, [CI, 0.979–1.000]; p = 0.043), and D-dimer (OR 5.313, [CI, 0.325–86.816]; p = 0.241) were independent predictors of disease severity.
has issue date	2020-04-24(xsd:dateTime)
bibo:doi	10.1016/j.jaut.2020.102473
bibo:pmid	32439209
has license	els-covid
sha1sum (hex)	a5a111d7df2808dce7812a47f3a86b94dd1eba9e
schema:url	https://doi.org/10.1016/j.jaut.2020.102473
resource representing a document's title	Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience
has PubMed Central identifier	PMC7180376
has PubMed identifier	32439209
schema:publication	J Autoimmun
resource representing a document's body	covid:a5a111d7df2808dce7812a47f3a86b94dd1eba9e#body_text
is schema:about of	named entity 'demographic' named entity 'male' named entity 'COVID-19' named entity 'levels' named entity 'feature' named entity 'investigated' named entity 'COVID-19' named entity 'Beijing' named entity 'CD8' named entity 'AGE' named entity 'MALE PREDOMINANCE' named entity 'DISEASE OUTBREAKS' named entity 'CRITICALLY ILL' named entity 'FEATURE' covid:arg/a5a111d7df2808dce7812a47f3a86b94dd1eba9e named entity 'liver function test' named entity 'mild' named entity 'moderate' named entity 'cough' named entity 'patients' named entity 'LDH' named entity 'critically ill' named entity 'numbers' named entity 'The' named entity 'CD8+ T lymphocytes' named entity 'B lymphocytes' named entity 'age' named entity 'Characteristics' named entity 'Beijing' named entity 'COVID-19' named entity 'patients' named entity 'eosinophils' named entity 'COVID-19' named entity 'infectious disease outbreaks' named entity 'NK cell' named entity 'albumin' named entity 'cough' named entity 'lymphocyte' named entity 'COVID-19' named entity 'critically ill patients' named entity 'lungs' named entity 'AST' named entity 'statistically significant' named entity 'eosinopenia' named entity 'severe diseases' named entity 'sputum production' named entity 'Adverse events' named entity 'China' named entity 'LDH' named entity 'Pneumonia' named entity 'Wuhan' named entity 'LDH' named entity 'China' named entity 'IL-6' named entity 'Spearman correlation' named entity 'virus' named entity 'viral infections' named entity 'etiology' named entity 'PaO2/FiO2' named entity 'infection' named entity 'Wuhan' named entity 'COVID-19' named entity 'CD4+ T lymphocyte' named entity 'cytokines' named entity 'Serum ferritin' named entity 'aspartate transaminase' named entity 'COVID-19' named entity 'Liver injury' named entity 'mycobacterium tuberculosis' named entity 'critically ill' named entity 'CD8+' named entity 'interferon-γ inducible protein 10' named entity 'National Health Commission of China'

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