About: Clathrin- and serine proteases-dependent uptake of porcine epidemic diarrhea virus into Vero cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clathrin- and serine proteases-dependent uptake of porcine epidemic diarrhea virus into Vero cells
Creator	Park, Jung-Eun Shin, Hyun-Jin Cruz, John
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine epidemic diarrhea virus (PEDV), a member of the genus Alphacoronavirus, is a causative agent of porcine enteric disease characterized by acute watery diarrhea and dehydration in sucking piglet. Similar to other coronaviruses, PEDV spike protein mediates its cell entry by binding to cellular receptors and inducing membrane fusion between viral envelopes and cellular membranes. However, the entry mechanism of PEDV is not studied. Here, we determined the entry mechanism of PEDV into Vero cells. Our data confirmed that PEDV entry followed clathrin-mediated endocytosis independence of caveolae-coated pit assembly. The internalized PEDV was co-localized with the clathrin-mediated endocytic marker, but not with the caveolae-mediated endocytic marker. In addition, cells treated with lysosomotropic agents and serine protease inhibitors were resistant to PEDV. Our data revealed that PEDV entry followed clathrin-mediated endocytosis and was dependent on a low pH and serine proteolysis for successful entry into cells.
has issue date	2014-10-13(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.07.022
bibo:pmid	25086180
has license	els-covid
sha1sum (hex)	a5d3af041bc25b45f1724fd5b97b265fa30ac274
schema:url	https://doi.org/10.1016/j.virusres.2014.07.022
resource representing a document's title	Clathrin- and serine proteases-dependent uptake of porcine epidemic diarrhea virus into Vero cells
has PubMed Central identifier	PMC7114442
has PubMed identifier	25086180
schema:publication	Virus Research
resource representing a document's body	covid:a5d3af041bc25b45f1724fd5b97b265fa30ac274#body_text
is schema:about of	named entity 'mechanism' named entity 'data' named entity 'Vero' named entity 'SERINE PROTEASES' named entity 'UPTAKE' named entity 'COATED PIT ASSEMBLY' named entity 'SUCKING' named entity 'BUT' named entity 'VIRAL' named entity 'RESISTANT TO' named entity 'PROTEOLYSIS' named entity 'PIGLET' named entity 'DISEASE' named entity 'ENTERIC' named entity 'CORONAVIRUSES' named entity 'DEHYDRATION' named entity 'FOLLOWED' named entity 'OUR' named entity 'MEDIATES' named entity 'TREATED WITH' named entity 'ITS' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'CLATHRIN-MEDIATED ENDOCYTOSIS' named entity 'SPIKE PROTEIN' named entity 'HERE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'DEPENDENT' named entity 'CELLS' named entity 'ACUTE' named entity 'DETERMINED' named entity 'INDEPENDENCE' named entity 'LOCALIZED' named entity 'INDUCING' named entity 'MEMBRANES' named entity 'CLATHRIN' named entity 'DEPENDENT' named entity 'CELL' named entity 'MEDIATED' named entity 'MEMBER OF' named entity 'CELLULAR' named entity 'VERO CELLS' named entity 'WATERY DIARRHEA' named entity 'CLATHRIN' named entity 'CAUSATIVE AGENT' named entity 'PORCINE' named entity 'MECHANISM' named entity 'DATA' named entity 'MARKER' named entity 'RECEPTORS' named entity 'GENUS ALPHACORONAVIRUS' named entity 'SERINE PROTEASE INHIBITORS' named entity 'ENDOCYTOSIS' named entity 'REVEALED' named entity 'PROTEIN ' named entity 'VERO CELLS' named entity 'CONFIRMED' named entity 'CAVEOLAE' named entity 'BINDING' named entity 'IS A' named entity 'SUCCESSFUL' named entity 'ENTRY' named entity 'LOW PH' named entity 'ADDITION' named entity 'SERINE' named entity 'MEMBRANE FUSION' named entity 'SIMILAR' named entity 'CHARACTERIZED' covid:arg/a5d3af041bc25b45f1724fd5b97b265fa30ac274 named entity 'agents' named entity 'envelopes' named entity 'protein' named entity 'causative' named entity 'acute' named entity 'protease inhibitors' named entity 'porcine' named entity 'PEDV' named entity 'cellular receptors' named entity 'serine' named entity 'enteric disease'

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