About: The role of procalcitonin as a guide for the diagnosis, prognosis, and decision of antibiotic therapy for lower respiratory tract infections

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About: The role of procalcitonin as a guide for the diagnosis, prognosis, and decision of antibiotic therapy for lower respiratory tract infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The role of procalcitonin as a guide for the diagnosis, prognosis, and decision of antibiotic therapy for lower respiratory tract infections
Creator	Abdulattif, Sherif Anwar, Enas Fawzy, Esmat Hamdy, Gehan Saraya, Mohamed Abd El-Azeem, Amal
topic	covid:a5f07c7aad9553b24ebb3a9c503e8931800bd820#this
Source	Elsevier; Medline; PMC
abstract	Abstract Objectives To assess the value of PCT as a rapid and sensitive marker for diagnosis, prognosis, and therapy of lower respiratory tract bacterial infections necessitating antimicrobial treatment and comparing this marker with other markers of infections including C-reactive protein (CRP) and total white-blood cell counts (WBCs). Patients and methods Sixty Patients were enrolled in the study, they were subjected to complete history taking, physical examination, laboratory investigations including complete blood count, blood gases, blood chemistry, bacteriological culture for sputum and blood, serology for atypicals, and PCR for respiratory viruses, serum C-reactive protein (CRP) and PCT levels were measured. The patients were divided into two groups, group 1 included 26 patients who were culture negative for bacterial infection and group 2 included 34 patients who were culture positive. Group 2 patients were given antibiotic therapy according to the culture sensitivity. Result The results revealed that, there was no significant difference between group 1 and group 2 patients as regards age, sex, clinical manifestations, final diagnosis, white blood cell counts, blood gases, number of admitted patients, intensive care unit admission and length of hospital stay. A significant increase of PCT and CRP levels was detected in group 2 compared to group 1 at initial diagnosis. At cutoff value >0.5ng/ml, PCT gave a sensitivity of 94.1%, specificity of 88.4%, positive predictive value (PPV) of 91.4%, negative predictive value (NPV) of 92% and diagnostic efficiency of 91.6% for diagnosis of respiratory tract bacterial infections. However, at a cutoff value >8mg/L, CRP gave a sensitivity of 85.2%, specificity of 76.9%, PPV of 82.8%, NPV of 80% and diagnostic efficiency of 81.7%. After antibiotic therapy PCT and CRP levels dropped in group 2 patients as compared to their pre-treatment levels. Conclusion Serum PCT level could be used as a novel marker of lower respiratory tract bacterial infections for diagnosis, prognosis and follow up of therapy. This reduces side-effects of an unnecessary antibiotic use, lowers costs, and in the long-term, leads to diminishing drug resistance.
has issue date	2013-10-31(xsd:dateTime)
bibo:doi	10.1016/j.ejcdt.2013.07.017
bibo:pmid	32288126
has license	els-covid
sha1sum (hex)	a5f07c7aad9553b24ebb3a9c503e8931800bd820
schema:url	https://doi.org/10.1016/j.ejcdt.2013.07.017
resource representing a document's title	The role of procalcitonin as a guide for the diagnosis, prognosis, and decision of antibiotic therapy for lower respiratory tract infections
has PubMed Central identifier	PMC7126862
has PubMed identifier	32288126
schema:publication	Egyptian Journal of Chest Diseases and Tuberculosis
resource representing a document's body	covid:a5f07c7aad9553b24ebb3a9c503e8931800bd820#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/a5f07c7aad9553b24ebb3a9c503e8931800bd820
is schema:about of	named entity 'diagnosis' named entity 'Chest' named entity 'HOSTING' named entity 'PROCALCITONIN' named entity 'LOWER RESPIRATORY TRACT INFECTIONS' named entity 'PROGNOSIS' named entity 'VALUE' named entity 'BLOOD CELL COUNTS' named entity 'SENSITIVE' named entity 'PCT' named entity 'TOTAL' named entity 'INCLUDING' named entity 'BACTERIAL INFECTIONS' named entity 'COMPARING' named entity 'GUIDE' named entity 'ASSESS' named entity 'FOR DIAGNOSIS' named entity 'WHITE' named entity 'INFECTIONS' named entity 'EGYPTIAN' named entity 'CHEST' named entity 'DECISION' named entity 'JOURNAL ' named entity 'DISEASES' named entity 'ROLE' named entity 'PRODUCTION' named entity 'MARKER' named entity 'THERAPY' named entity 'OBJECTIVES' named entity 'RAPID' named entity 'PROTEIN ' named entity 'LOWER RESPIRATORY TRACT' named entity 'ANTIBIOTIC THERAPY' named entity 'DIAGNOSIS' named entity 'PROGNOSIS' named entity 'TUBERCULOSIS' named entity 'C-REACTIVE PROTEIN' named entity 'OTHER MARKERS' covid:arg/a5f07c7aad9553b24ebb3a9c503e8931800bd820 named entity 'antimicrobial' named entity 'Objectives' named entity 'respiratory tract infections' named entity 'Production' named entity 'WBCs' named entity 'C-reactive protein' named entity 'antimicrobial' named entity 'Tuberculosis' named entity 'lower respiratory tract infections' named entity 'Elsevier' named entity 'ng/mL' named entity 'antibiotic therapy' named entity 'CRP' named entity 'pneumonia severity index' named entity 'antibiotic therapy' named entity 'pneumonia' named entity 'COPD' named entity 'detection limit' named entity 'ester' named entity 'Septic shock' named entity 'antibiotic therapy' named entity 'PPV' named entity 'bacterial infections' named entity 'cytokines' named entity 'pneumonia' named entity 'ng/mL' named entity 'antibiotics' named entity 'lower respiratory tract infections' named entity 'significant difference' named entity 'cardiogenic shock' named entity 'bacteria' named entity 'atypicals' named entity 'etiologies' named entity 'small cell lung cancer' named entity 'PCR'

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