About: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells

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About: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells
Creator	Law, Helen Cheung, Chung Lau, Yu Chan, Yuk Peiris, Js
Source	Medline; PMC
abstract	BACKGROUND: The SARS outbreak in 2003 provides a unique opportunity for the study of human responses to a novel virus. We have previously reported that dendritic cells (DCs) might be involved in the immune escape mechanisms for SARS-CoV. In this study, we focussed on the gene expression of toll-like receptors (TLRs), chemokine receptors (CCRs) and death receptor ligands in SARS-CoV infected DCs. We also compared adult and cord blood (CB) DCs to find a possible explanation for the age-dependent severity of SARS. RESULTS: Our results demonstrates that SARS-CoV did not modulate TLR-1 to TLR-10 gene expression but significantly induced the expression of CCR-1, CCR-3, and CCR-5. There was also strong induction of TNF-related apoptosis-inducing ligand (TRAIL), but not Fas ligand gene expression in SARS-CoV infected DCs. Interestingly, the expressions of most genes studied were higher in CB DCs than adult DCs. CONCLUSION: The upregulation of chemokines and CCRs may facilitate DC migration from the infection site to the lymph nodes, whereas the increase of TRAIL may induce lymphocyte apoptosis. These findings may explain the increased lung infiltrations and lymphoid depletion in SARS patients. Further explorations of the biological significance of these findings are warranted.
has issue date	2009-06-08(xsd:dateTime)
bibo:doi	10.1186/1471-2172-10-35
bibo:pmid	19505311
has license	cc-by
sha1sum (hex)	a600310d78ebe675d0d7bc5d9188a77d73e0e79a
schema:url	https://doi.org/10.1186/1471-2172-10-35
resource representing a document's title	Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells
has PubMed Central identifier	PMC2700820
has PubMed identifier	19505311
schema:publication	BMC Immunol
resource representing a document's body	covid:a600310d78ebe675d0d7bc5d9188a77d73e0e79a#body_text
is schema:about of	named entity '2003' named entity 'TOLL-LIKE RECEPTORS' named entity 'DEATH RECEPTOR' named entity 'CHEMOKINE RECEPTORS' covid:arg/a600310d78ebe675d0d7bc5d9188a77d73e0e79a named entity 'DEATH RECEPTOR' named entity 'OPPORTUNITY' named entity 'PROVIDES' named entity 'PREVIOUSLY' named entity 'REPORTED' named entity 'SARS' named entity 'INFECTED' named entity 'NOVEL' named entity 'MECHANISMS' named entity 'HAVE' named entity 'OUTBREAK' named entity 'LIGANDS' named entity 'UNIQUE' named entity 'CHEMOKINE RECEPTORS' named entity 'RESPONSES' named entity 'LIGANDS' named entity 'IMMUNE' named entity 'STUDY' named entity 'HUMAN' named entity 'EXPLANATION' named entity 'VIRUS' named entity 'BMC' named entity 'RESPONSES' named entity 'HUMAN MONOCYTE' named entity 'DENDRITIC CELLS' named entity 'INFECTED HUMAN' named entity 'SARS CORONAVIRUS' named entity 'INVOLVED' named entity 'DENDRITIC CELLS' named entity 'DCS' named entity 'POSSIBLE' named entity 'CORD BLOOD' named entity 'SARS-COV' named entity 'AGE' named entity 'TOLL-LIKE RECEPTORS' named entity 'MIGHT BE' named entity 'ESCAPE' named entity 'COMPARED' named entity 'ADULT' named entity 'SEVERITY' named entity 'IMMUNOLOGY' named entity 'DERIVED' named entity 'DEPENDENT' named entity 'GENE EXPRESSION' named entity 'mechanisms' named entity 'gene' named entity 'virus' named entity 'SARS coronavirus' named entity 'DCs' named entity 'chemokine receptors' named entity 'death receptor' named entity 'Toll-like receptors' named entity 'death receptor' named entity 'monocyte' named entity 'SARS-CoV' named entity 'DCs' named entity 'signaling pathways' named entity 'GM-CSF' named entity 'TLR-4' named entity 'β-actin' named entity 'dendritic cells' named entity 'lymphopenia' named entity 'DCs' named entity 'TLR' named entity 'gene' named entity 'TLR' named entity 'Viruses' named entity 'IFNα' named entity 'TLR-1' named entity 'antigen presentation' named entity 'tumor necrosis factor (TNF)-α' named entity 'CCR-5'

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