About: Priming with SARS CoV S DNA and boosting with SARS CoV S epitopes specific for CD4+ and CD8+ T cells promote cellular immune responses

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Priming with SARS CoV S DNA and boosting with SARS CoV S epitopes specific for CD4+ and CD8+ T cells promote cellular immune responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Priming with SARS CoV S DNA and boosting with SARS CoV S epitopes specific for CD4+ and CD8+ T cells promote cellular immune responses
Creator	Bu, Xianzhang Cao, Yingnan Du, Jiali Huang, Jun Ma, Rui Wu, Changyou
Source	Elsevier; Medline; PMC
abstract	Abstract Cellular immune response plays an important role in antiviral immunity. In our previous study, immunization of mice with severe acute respiratory syndrome coronavirus (SARS CoV) spike (S) DNA vaccine could induce both humoral and cellular immunity in response to a pool of entire overlapping S peptides. Identification of functional dominant epitopes in SARS CoV S protein for T cells is crucial for further understanding of cellular immune responses elicited by SARS CoV S DNA vaccine. In present study, mice were immunized with SARS CoV S DNA vaccine. Subsequently, a pool of 17–19 mers overlapped SARS CoV S peptides, which served as immunogens, were scanned to identify the specific epitopes for T cells. Two H-2d restricted CD4+ T epitopes, N60 (S435–444) and P152 (S1111–1127), and two H-2d restricted CD8+ T cell epitopes, N50 (S365–374) and P141 (S1031–1047) were identified by three different methods, enzyme-linked immunosorbent assay (ELISA), enzyme linked immunospot assay (ELISPOT) and fluorescence activated cell sorter (FACS). The dominant CD4+ T cell epitope (N60) and CD8+ T cell epitope (N50) located in the receptor-binding domain (RBD) of SARS CoV S protein, which mediated virus combining and fusing to susceptible cells. Importantly, our novel finding is that mice primed with SARS S DNA vaccine and boosted with T cell epitopes (N50 and N60) could promote antigen specific CD4+ and CD8+ T cell immune responses. Our study provides valuable information for the design of vaccine for SARS study.
has issue date	2007-09-28(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2007.06.047
bibo:pmid	17709158
has license	els-covid
sha1sum (hex)	a61e707ef1a808123b3c6f542a79373d4315d603
schema:url	https://doi.org/10.1016/j.vaccine.2007.06.047
resource representing a document's title	Priming with SARS CoV S DNA and boosting with SARS CoV S epitopes specific for CD4+ and CD8+ T cells promote cellular immune responses
has PubMed Central identifier	PMC7115420
has PubMed identifier	17709158
schema:publication	Vaccine
resource representing a document's body	covid:a61e707ef1a808123b3c6f542a79373d4315d603#body_text
is schema:about of	named entity 'T CELLS' named entity 'SARS' named entity 'IMMUNE RESPONSES' named entity 'FUNCTIONAL' named entity 'DOMAIN' named entity 'T CELL EPITOPE' named entity 'LOCATED IN' named entity 'DESIGN' named entity 'H-2' named entity 'PRESENT' named entity 'STUDY' named entity 'VIRUS' named entity 'BINDING' named entity 'OUR' named entity 'ENTIRE' named entity 'INFORMATION' named entity '1127' named entity 'TO IDENTIFY' named entity 'POOL' named entity 'SPECIFIC' named entity 'OVERLAPPED' named entity 'MEDIATED' named entity 'RECEPTOR' named entity 'RESTRICTED' named entity 'PROVIDES' named entity 'DOMINANT' named entity 'PROTEIN ' named entity 'IMPORTANT' named entity 'DIFFERENT' named entity 'PREVIOUS' named entity 'BOOSTING' named entity 'EPITOPES' named entity 'PROMOTE' named entity 'DNA' named entity 'PEPTIDES' named entity 'IMMUNOGENS' named entity 'ANTIGEN SPECIFIC' named entity 'CD4' named entity 'CD8' named entity 'CELLULAR' named entity 'SPECIFIC' named entity 'PRIMING' named entity 'T CELL' named entity 'PRIMED' named entity 'N60' named entity 'CELLS' named entity 'MICE' named entity 'MERS' named entity 'SCANNED' named entity 'ANTIVIRAL' named entity 'PLAYS' named entity 'DNA VACCINE' named entity 'NOVEL' named entity 'COMBINING' named entity 'FINDING' named entity 'CELLULAR' named entity 'IMMUNIZED' named entity 'UNDERSTANDING' named entity 'INDUCE' named entity 'METHODS' named entity 'PROMOTE' named entity 'CELLULAR IMMUNITY' named entity 'IDENTIFICATION' named entity 'N50' named entity 'CD4' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAY' named entity 'IDENTIFIED BY' named entity 'T CELLS' named entity 'OVERLAPPING' named entity 'IMMUNE RESPONSES' named entity 'S PROTEIN' named entity 'FLUORESCENCE ACTIVATED CELL SORTER' named entity 'SUSCEPTIBLE' named entity 'SPIKE' named entity 'SARS' named entity 'RESPONSE TO'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software