About: Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility

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About: Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility
Creator	Dutta, Shanta Chawla Sarkar, Mamta Banu, Hasina Biswas, Nidhan Chakraborti, Sohini Chatterjee, Ananya Chinnaswamy, Sreedhar Das, Saumitra Ghosh, Shekhar Ghosh, Trinath Maitra, Arindam Majumdar, Agniva Patra, Subrata Raheja, Harsha Sarkar, Sumanta Srinivasan, Narayanaswamy Kumar Mondal, Rajiv Kumar Singh, Animesh
Source	PMC
abstract	Direct massively parallel sequencing of SARS-CoV-2 genome was undertaken from nasopharyngeal and oropharyngeal swab samples of infected individuals in Eastern India. Seven of the isolates belonged to the A2a clade, while one belonged to the B4 clade. Specific mutations, characteristic of the A2a clade, were also detected, which included the P323L in RNA-dependent RNA polymerase and D614G in the Spike glycoprotein. Further, our data revealed emergence of novel subclones harbouring nonsynonymous mutations, viz. G1124V in Spike (S) protein, R203K, and G204R in the nucleocapsid (N) protein. The N protein mutations reside in the SR-rich region involved in viral capsid formation and the S protein mutation is in the S(2) domain, which is involved in triggering viral fusion with the host cell membrane. Interesting correlation was observed between these mutations and travel or contact history of COVID-19 positive cases. Consequent alterations of miRNA binding and structure were also predicted for these mutations. More importantly, the possible implications of mutation D614G (in S(D) domain) and G1124V (in S(2) subunit) on the structural stability of S protein have also been discussed. Results report for the first time a bird’s eye view on the accumulation of mutations in SARS-CoV-2 genome in Eastern India. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12038-020-00046-1) contains supplementary material, which is available to authorized users.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1007/s12038-020-00046-1
has license	no-cc
sha1sum (hex)	a6260fdfd903e7c8949e423f9fca742acc893e58
schema:url	https://doi.org/10.1007/s12038-020-00046-1
resource representing a document's title	Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility
has PubMed Central identifier	PMC7269891
schema:publication	J Biosci
resource representing a document's body	covid:a6260fdfd903e7c8949e423f9fca742acc893e58#body_text
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