About: Phosphorylation of p38 MAPK and its downstream targets in SARS coronavirus-infected cells

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About: Phosphorylation of p38 MAPK and its downstream targets in SARS coronavirus-infected cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phosphorylation of p38 MAPK and its downstream targets in SARS coronavirus-infected cells
Creator	Mizutani, Tetsuya Fukushi, Shuetsu Morikawa, Shigeru Saijo, Masayuki Kurane, Ichiro
Source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome (SARS) has become a global public health emergency. Understanding the molecular mechanisms of SARS-induced cytopathic effects (CPEs) is a rational approach for the prevention of SARS, and an understanding of the cellular stress responses induced by viral infection is important for understanding the CPEs. Polyclonal antibodies, which recognized nucleocapsid (N) and membrane (M) proteins, detected viral N and M proteins in virus-infected Vero E6 cells at least 6 and 12h post-infection (h.p.i.), respectively. Furthermore, detection of DNA ladder and cleaved caspase-3 in the virus-infected cells at 24h.p.i. indicated that SARS-CoV infection induced apoptotic cell death. Phosphorylation of p38 MAPK was significantly up-regulated at 18h.p.i. in SARS-CoV-infected cells. The downstream targets of p38 MAPK, MAPKAPK-2, HSP-27, CREB, and eIF4E were phosphorylated in virus-infected cells. The p38 MAPK inhibitor, SB203580, inhibited effectively phosphorylation of HSP-27, CREB, and eIF4E in SARS-CoV-infected cells. However, viral protein synthesis was not affected by treatment of SB203580.
has issue date	2004-07-09(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2004.05.107
bibo:pmid	15194498
has license	els-covid
sha1sum (hex)	a6529715bc34fce68e08780be0b80acdc823e744
schema:url	https://doi.org/10.1016/j.bbrc.2004.05.107
resource representing a document's title	Phosphorylation of p38 MAPK and its downstream targets in SARS coronavirus-infected cells
has PubMed Central identifier	PMC7111015
has PubMed identifier	15194498
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:a6529715bc34fce68e08780be0b80acdc823e744#body_text
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