About: eIF3f: A central regulator of the antagonism atrophy/hypertrophy in skeletal muscle()

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About: eIF3f: A central regulator of the antagonism atrophy/hypertrophy in skeletal muscle() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	eIF3f: A central regulator of the antagonism atrophy/hypertrophy in skeletal muscle()
Creator	Bernardi, Henri Csibi, Alfredo Docquier, Aurélie Lagirand-Cantaloube, Julie Leibovitch, Marie-Pierre Raibon, Audrey Sanchez, Anthony Leibovitch, Serge
Source	Elsevier; Medline; PMC
abstract	The eukaryotic initiation factor 3 subunit f (eIF3f) is one of the 13 subunits of the translation initiation factor complex eIF3 required for several steps in the initiation of mRNA translation. In skeletal muscle, recent studies have demonstrated that eIF3f plays a central role in skeletal muscle size maintenance. Accordingly, eIF3f overexpression results in hypertrophy through modulation of protein synthesis via the mTORC1 pathway. Importantly, eIF3f was described as a target of the E3 ubiquitin ligase MAFbx/atrogin-1 for proteasome-mediated breakdown under atrophic conditions. The biological importance of the MAFbx/atrogin-1-dependent targeting of eFI3f is highlighted by the finding that expression of an eIF3f mutant insensitive to MAFbx/atrogin-1 polyubiquitination is associated with enhanced protection against starvation-induced muscle atrophy. A better understanding of the precise role of this subunit should lead to the development of new therapeutic approaches to prevent or limit muscle wasting that prevails in numerous physiological and pathological states such as immobilization, aging, denervated conditions, neuromuscular diseases, AIDS, cancer, diabetes. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting.
has issue date	2013-06-13(xsd:dateTime)
bibo:doi	10.1016/j.biocel.2013.06.001
bibo:pmid	23769948
has license	no-cc
sha1sum (hex)	a67dae6e5f2b58a6f16aaed4011c694f9e64dd88
schema:url	https://doi.org/10.1016/j.biocel.2013.06.001
resource representing a document's title	eIF3f: A central regulator of the antagonism atrophy/hypertrophy in skeletal muscle()
has PubMed Central identifier	PMC7108353
has PubMed identifier	23769948
schema:publication	Int J Biochem Cell Biol
resource representing a document's body	covid:a67dae6e5f2b58a6f16aaed4011c694f9e64dd88#body_text
is schema:about of	named entity 'steps' named entity 'diabetes' named entity 'skeletal muscle' named entity 'antagonism' named entity 'ANTAGONISM' named entity 'EIF3' named entity 'CANCER' named entity 'MUSCLE WASTING' named entity 'PLAYS' named entity 'ENHANCED' named entity 'FINDING' named entity 'OVEREXPRESSION' named entity 'POLYUBIQUITINATION' named entity 'CONDITIONS' named entity 'DEMONSTRATED' named entity 'THERAPEUTIC' named entity 'ONE OF' named entity 'UNDERSTANDING' named entity 'TARGET' named entity 'CENTRAL' named entity 'EUKARYOTIC INITIATION FACTOR 3' named entity 'RESULTS' named entity 'STUDIES' named entity 'NEW' named entity 'MAINTENANCE' named entity 'PROTEASOME' named entity 'PROTECTION' named entity 'NEUROMUSCULAR DISEASES' named entity 'NUMEROUS' named entity 'STATES' named entity 'PROTEIN SYNTHESIS' named entity 'INDUCED' named entity 'REQUIRED' named entity 'AIDS' named entity 'DIABETES' named entity 'BIOLOGICAL' named entity 'MUSCLE ATROPHY' named entity 'TRANSLATION INITIATION FACTOR' named entity 'INITIATION' named entity 'DEPENDENT' named entity 'PATHOLOGICAL' named entity 'EXPRESSION' named entity 'SIZE' named entity 'MAFBX' named entity 'EIF3F' named entity 'STEPS' named entity 'STARVATION' named entity 'PATHWAY' named entity 'AGING' named entity 'HAVE' named entity 'DENERVATED' named entity 'ROLE' named entity 'APPROACHES' named entity 'MODULATION' named entity 'MRNA TRANSLATION' named entity 'CENTRAL' named entity 'REGULATOR' named entity 'ATROPHY' named entity 'EIF3F' named entity 'IMMOBILIZATION' named entity 'BREAKDOWN' named entity 'LIMIT' named entity 'BETTER' named entity 'MUTANT' named entity 'INSENSITIVE' named entity 'COMPLEX' named entity 'PRECISE' named entity 'SKELETAL MUSCLE' named entity 'DEVELOPMENT' named entity 'E3 UBIQUITIN LIGASE' named entity 'TARGETING' named entity 'LEAD' named entity 'HYPERTROPHY' named entity 'DESCRIBED'

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