About: Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease
Creator	Miller, Stephen Chastain, Emily
source	Medline; PMC
abstract	Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that affects about 0.1% of the worldwide population. This deleterious disease is marked by infiltration of myelinspecific T cells that attack the protective myelin sheath that surrounds CNS nerve axons. Upon demyelination, saltatory nerve conduction is disrupted, and patients experience neurologic deficiencies. The exact cause for MS remains unknown, although most evidence supports the hypothesis that both genetic and environmental factors contribute to disease development. Epidemiologic evidence supports a role for environmental pathogens, such as viruses, as potentially key contributors to MS induction. Pathogens can induce autoimmunity via several well-studied mechanisms with the most postulated being molecular mimicry. Molecular mimicry occurs when T cells specific for peptide epitopes derived from pathogens cross-react with self-epitopes, leading to autoimmune tissue destruction. In this review, we discuss an in vivo virus-induced mouse model of MS developed in our laboratory, which has contributed greatly to our understanding of the mechanisms underlying molecular mimicry-induced CNS autoimmunity.
has issue date	2011-12-15(xsd:dateTime)
bibo:doi	10.1111/j.1600-065x.2011.01076.x
bibo:pmid	22168423
has license	green-oa
sha1sum (hex)	a6ae0b0a1b76a367c6a95d58052c65b2c5feb850
schema:url	https://doi.org/10.1111/j.1600-065x.2011.01076.x
resource representing a document's title	Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease
has PubMed Central identifier	PMC3586283
has PubMed identifier	22168423
schema:publication	Immunological Reviews
resource representing a document's body	covid:a6ae0b0a1b76a367c6a95d58052c65b2c5feb850#body_text
is schema:about of	named entity 'genetic' named entity 'vivo' named entity 'remains' named entity 'environmental factors' named entity 'viruses' named entity 'nerve conduction' named entity 'DELETERIOUS' named entity 'ABOUT' named entity 'EPITOPES' named entity 'DEVELOPMENT' named entity 'UNDERLYING' named entity 'NEUROLOGIC' named entity 'GREATLY' named entity 'VIRUSES' named entity 'ROLE' named entity 'GENETIC' named entity 'BEING' named entity 'CNS' named entity 'T CELLS' named entity 'POPULATION' named entity 'ATTACK' named entity 'TISSUE' named entity 'PEPTIDE' named entity 'INDUCTION' named entity 'ENVIRONMENTAL' named entity 'AXONS' named entity 'MYELIN SHEATH' named entity 'EPIDEMIOLOGIC' named entity 'AUTOIMMUNITY' named entity 'IN VIVO' named entity 'EVIDENCE' named entity 'UNDERSTANDING' named entity 'UNKNOWN' named entity 'MECHANISMS' named entity 'PATIENTS' named entity 'LABORATORY' named entity 'SPECIFIC' named entity 'MODEL OF' named entity 'CONTRIBUTE ' named entity 'REVIEW' named entity 'CAUSE' named entity 'DEMYELINATION' named entity 'MOUSE MODEL' named entity 'DISEASE' named entity 'PATHOGENS' named entity 'WORLDWIDE' named entity 'LEADING' named entity 'OUR' named entity 'AUTOIMMUNE DISEASE' named entity 'NERVE ' named entity 'HYPOTHESIS' named entity 'MOLECULAR MIMICRY' named entity 'DISCUSS' named entity 'AUTOIMMUNE' named entity 'INDUCING' named entity 'CNS' named entity 'AUTOIMMUNE DEMYELINATING DISEASE' named entity 'TRIGGER' named entity 'CROSS' named entity 'DESTRUCTION' named entity 'EXACT' named entity 'DISRUPTED' named entity 'INFILTRATION' named entity 'MARKED' named entity 'MULTIPLE SCLEROSIS' named entity 'INDUCE' named entity 'EXPERIENCE' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'ENVIRONMENTAL FACTORS' named entity '0.1' named entity 'INDUCED' named entity 'NERVE CONDUCTION' named entity 'KEY' named entity 'SURROUNDS' named entity 'DERIVED' named entity 'REACT' named entity 'MOLECULAR MIMICRY' covid:arg/a6ae0b0a1b76a367c6a95d58052c65b2c5feb850 named entity 'autoimmune disease' named entity 'disrupted'

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