About: Ebola virus glycoprotein with increased infectivity dominated the 2013

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About: Ebola virus glycoprotein with increased infectivity dominated the 2013–2016 epidemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ebola virus glycoprotein with increased infectivity dominated the 2013–2016 epidemic
Creator	Luban, Jeremy Andersen, Kristian Grubaugh, Nathan Lin, Aaron Sabeti, Pardis Diehl, William
Source	Elsevier; Medline; PMC
abstract	The magnitude of the 2013–2016 Ebola virus disease (EVD) epidemic enabled an unprecedented number of viral mutations to occur over successive human-to-human transmission events, increasing the probability that adaptation to the human host occurred during the outbreak. We investigated one nonsynonymous mutation, Ebola virus (EBOV) glycoprotein (GP) mutant A82V, for its effect on viral infectivity. This mutation, located at the NPC1-binding site on EBOV GP, occurred early in the 2013–2016 outbreak and rose to high frequency. We found that GP-A82V had heightened ability to infect primate cells, including human dendritic cells. The increased infectivity was restricted to cells that have primate-specific NPC1 sequences at the EBOV interface, suggesting that this mutation was indeed an adaptation to the human host. GP-A82V was associated with increased mortality, consistent with the hypothesis that the heightened intrinsic infectivity of GP-A82V contributed to disease severity during the EVD epidemic.
has issue date	2016-11-01(xsd:dateTime)
bibo:doi	10.1016/j.cell.2016.10.014
bibo:pmid	27814506
has license	hybrid-oa
sha1sum (hex)	a6cf4056a15f3c6d3b006850b993fe204415b22f
schema:url	https://doi.org/10.1016/j.cell.2016.10.014
resource representing a document's title	Ebola virus glycoprotein with increased infectivity dominated the 2013–2016 epidemic
has PubMed Central identifier	PMC5115602
has PubMed identifier	27814506
schema:publication	Cell
resource representing a document's body	covid:a6cf4056a15f3c6d3b006850b993fe204415b22f#body_text
is schema:about of	named entity 'glycoprotein' named entity 'infects' named entity 'Abstract' named entity 'Ebola' named entity 'infectivity' named entity 'San Diego' named entity 'influenza' named entity 'viral load' named entity 'primate species' named entity 'nucleotide substitution' named entity 'infection' named entity 'covalently bound' named entity 'nucleotide' named entity 'cell line' named entity 'goat' named entity 'amino acid' named entity 'non-human primates' named entity '3T3' named entity 'EBOV' named entity 'genotype' named entity 'La Jolla' named entity 'Nucleotide' named entity 'genotype' named entity 'protein production' named entity 'EVD' named entity 'virus' named entity 'lentiviral particles' named entity 'viremia' named entity 'valine' named entity 'R85' named entity 'Guinea' named entity 'C-terminal' named entity 'CDC' named entity 'GM-CSF' named entity 'virus-like particles' named entity 'Triton X-100' named entity 'genotype' named entity 'HIV-1 and HIV-2' named entity 'EBOV' named entity 'amino acid' named entity 'cytokine' named entity 'demand for health' named entity 'St. Louis' named entity 'Infection' named entity 'recombinant' named entity 'Coralville' named entity 'viral load' named entity 'antibodies' named entity 'virion' named entity 'amino acids' named entity 'VP40' named entity 'glycoprotein' named entity 'genotype' named entity 'transduce' named entity 'EBOV' named entity 'health care' named entity 'NPC1' named entity 'EBOV' named entity 'EBOV' named entity 'EBOV' named entity 'infection' named entity '2013-2016' named entity 'primate species' named entity 'monoclonal antibody' named entity 'viral load' named entity 'Virus-like particles' named entity 'VP40' named entity 'K.G.' named entity 'Maximum likelihood' named entity 'sucrose' named entity 'RNA' named entity 'viral particles' named entity 'EBOV' named entity 'EVD' named entity 'correlation' named entity 'viral infections'

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