About: Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary report

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary report
Creator	Palma, Paolo Campana, Andrea Cotugno, Nicola Valente, Paola Buzzonetti, Luca De Ioris, Maria Federici, Matteo Iarossi, Giancarlo Petroni, Sergio
source	Elsevier; Medline; PMC
abstract	Abstract Purpose To evaluate ocular manifestations and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) prevalence in the tears of children with coronavirus disease 2019 (COVID-19). Methods A total of 27 pediatric patients with confirmed COVID-19 infection hospitalized from March 16 to April 15, 2020, at the Bambino Gesù Children’s Hospital were enrolled in the study. At admission, all patients showed ocular manifestations. Reverse transcriptase–polymerase chain reaction from nasopharyngeal and conjunctival swabs were performed every 2-3 days before discharge. Results Of the 27 patients, 4 (15%) were asymptomatic, 15 (56%) showed respiratory symptoms, and 8 (30%) had gastrointestinal symptoms. At admission, nasopharyngeal swabs were positive for COVID-19 in all patients; on the second swabs, 7 children (26%) tested negative, and 20 remained positive for COVID-19. Ocular manifestations consistent with mild viral conjunctivitis were observed in 4 patients (15%). At first conjunctival swab, 3 patients (11%), 1 symptomatic and 2 asymptomatic for ocular infection, had positive findings for COVID-19; 2 became negative on the second test and 1 on the third. Conclusions In our study cohort, ocular manifestations of COVID-19 seem to have had a milder clinical course in pediatric patients than in adults. Despite the low prevalence and rapid regression of viral presence in the conjunctiva, SARS-CoV-2 transmission through tears may be possible, even in patients without apparent ocular involvement.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1016/j.jaapos.2020.05.002
bibo:pmid	32531341
has license	els-covid
sha1sum (hex)	a6e484d28090fa52d811b920a6fce3c5f7b88abb
schema:url	https://doi.org/10.1016/j.jaapos.2020.05.002
resource representing a document's title	Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary report
has PubMed Central identifier	PMC7282793
has PubMed identifier	32531341
schema:publication	J AAPOS
resource representing a document's body	covid:a6e484d28090fa52d811b920a6fce3c5f7b88abb#body_text
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