About: Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes
Creator	Fukushi, Shuetsu Saijo, Masayuki Yoshikawa, Tomoki Fujii, Hikaru Harada, Shizuko Inagaki, Takuya Shibamura, Miho Yamada, Souichi Nguyen, Anh Hoang, Phu Mizuguchi, Masashi Oka, Akira
Source	PMC
abstract	BACKGROUND: Human cytomegalovirus (HCMV) causes asymptomatic infections, but also causes congenital infections when women were infected with HCMV during pregnancy, and life-threatening diseases in immunocompromised patients. To better understand the mechanism of the neutralization activity against HCMV, the association of HCMV NT antibody titers was assessed with the antibody titers against each glycoprotein complex (gc) of HCMV. METHODS: Sera collected from 78 healthy adult volunteers were used. HCMV Merlin strain and HCMV clinical isolate strain 1612 were used in the NT assay with the plaque reduction assay, in which both the MRC-5 fibroblasts cells and the RPE-1 epithelial cells were used. Glycoprotein complex of gB, gH/gL complexes (gH/gL/gO and gH/gL/UL128–131A [PC]) and gM/gN were selected as target glycoproteins. 293FT cells expressed with gB, gM/gN, gH/gL/gO, or PC, were prepared and used for the measurement of the antibody titers against each gc in an indirect immunofluorescence assay (IIFA). The correlation between the IIFA titers to each gc and the HCMV-NT titers was evaluated. RESULTS: There were no significant correlations between gB-specific IIFA titers and the HCMV-NT titers in epithelial cells or between gM/gN complex-specific IIFA titers and the HCMV-NT titers. On the other hand, there was a statistically significant positive correlation between the IIFA titers to gH/gL complexes and HCMV-NT titers. CONCLUSIONS: The data suggest that the gH/gL complexes might be the major target to induce NT activity against HCMV.
has issue date	2020-08-03(xsd:dateTime)
bibo:doi	10.1186/s12985-020-01390-2
has license	cc-by
sha1sum (hex)	a6ef66cd5275e186d2bc36ec9c483e0c9c4b46f5
schema:url	https://doi.org/10.1186/s12985-020-01390-2
resource representing a document's title	Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes
has PubMed Central identifier	PMC7397426
schema:publication	Virol J
resource representing a document's body	covid:a6ef66cd5275e186d2bc36ec9c483e0c9c4b46f5#body_text
is schema:about of	named entity 'HCMV' named entity 'pregnancy' named entity 'antibody' named entity 'titers' named entity 'infections' named entity 'infected' named entity 'HCMV' named entity 'pregnancy' named entity 'life-threatening diseases' named entity 'glycoprotein' named entity 'antibodies' named entity 'HCMV' named entity 'staining' named entity 'Thermo Fisher Scientific' named entity 'glycosylation' named entity 'Human cytomegalovirus' named entity 'pregnant women' named entity 'HCMV' named entity 'antibody titer' named entity 'nucleotide sequence' named entity 'antigens' named entity 'antibodies' named entity 'fixed cells' named entity 'serum samples' named entity 'HCMV' named entity 'antibody' named entity 'antibody' named entity 'ECs' named entity 'HCMV' named entity 'antibodies' named entity 'antibody' named entity 'transfected' named entity '0.01' named entity 'epithelial cell' named entity 'infection' named entity 'complement' named entity 'antibodies' named entity 'fibroblasts' named entity 'HCMV' named entity 'ECs' named entity 'fibroblast cells' named entity 'antibody' named entity 'antibody' named entity 'MRC-5' named entity 'antibodies' named entity 'HCMV' named entity 'antibody' named entity 'freeze-thaw cycle' named entity 'HCMV' named entity 'HCMV' named entity 'transplacental' named entity 'San Diego' named entity 'conjugated' named entity 'fusion protein' named entity 'IgG' named entity 'homology' named entity 'primers' named entity 'DyLight' named entity 'endogenous' named entity 'antibodies' named entity 'HCMV' named entity 'HCMV' named entity 'pentameric' named entity 'epitopes' named entity 'antigen' named entity 'Coralville' named entity 'ORF' named entity 'Genomics' named entity 'methanol' named entity 'College Station, TX' named entity 'antibodies' named entity 'STATA'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software