About: Predictive risk factors for postoperative pneumonia after heart transplantation

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Predictive risk factors for postoperative pneumonia after heart transplantation
Creator	Leprince, Pascal Bouglé, Adrien James, Arthur Amour, Julien Coutance, Guillaume Dureau, Pauline Pasqualotto, Romain Rasata, Julie Varnous, Shaida Vidal, Charles
source	PMC
abstract	BACKGROUND: Pneumonia is a frequent complication in patients undergoing heart transplantation (HTx) that increases morbidity and mortality in this population. Nevertheless, the risk factors for postoperative pneumonia (POP) are still unknown. The aim of this study was to investigate the predictive risk factors for POP in HTx recipients. METHODS: In this retrospective study, all patients undergoing HTx between January 2014 and December 2015 were included. All cases of POP occurring until hospital discharge were investigated. The study aimed to determine risk factors using univariate and multivariate Cox regression models. Data are expressed in Odds Ratio [95% CI]. P < 0.05 was necessary to reject the null hypothesis. RESULTS: A total of 175 patients were included without any patients being lost to follow-up, and 89 instances of POP were diagnosed in 59 (34%) patients. Enterobacteriaceae and Pseudomonas aeruginosa were the most common pathogens. In the multivariate analysis, the risk factors were preoperative mechanical ventilation (OR 1.42 [1.12–1.80], P < 0.01) and perioperative blood transfusion (OR 1.42 [95% CI: 1.20–1.70], P < 0.01). POP significantly impacted mortality at 30 days (OR: 4 [1.3–12.4], P = 0.01) and 1 year (OR: 6.8 [2.5–8.4], P < 0.01) and was associated with a longer duration of mechanical ventilation, time to weaning from venoarterial extracorporeal membrane oxygenation and stay in an intensive care unit. Plasma exchanges and intravenous administration of immunoglobulins did not increase the risk of POP. CONCLUSION: After HTx, preoperative mechanical ventilation and blood transfusion were risk factors for POP and were associated with increased mortality. Enterobacteriaceae and Pseudomonas aeruginosa are the most common pathogens of POP.
has issue date	2020-01-07(xsd:dateTime)
bibo:doi	10.1186/s12871-019-0923-3
bibo:pmid	31910812
has license	cc-by
sha1sum (hex)	a71c4aea97f1e1fd9cd4123b393ed045d2e2c2a7
schema:url	https://doi.org/10.1186/s12871-019-0923-3
resource representing a document's title	Predictive risk factors for postoperative pneumonia after heart transplantation
has PubMed Central identifier	PMC6947950
has PubMed identifier	31910812
schema:publication	BMC Anesthesiol
resource representing a document's body	covid:a71c4aea97f1e1fd9cd4123b393ed045d2e2c2a7#body_text
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