About: Torsional restraint: a new twist on frameshifting pseudoknots

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Torsional restraint: a new twist on frameshifting pseudoknots
Creator	Meskauskas, A Dinman, Jonathan Plant, Ewan Baxter, J Dinman, J Harger, J Jacobs, J Jacobs, K Petrov, A
source	PMC
abstract	mRNA pseudoknots have a stimulatory function in programmed −1 ribosomal frameshifting (−1 PRF). Though we previously presented a model for how mRNA pseudoknots might activate the mechanism for −1 PRF, it did not address the question of the role that they may play in positioning the mRNA relative to the ribosome in this process [E. P. Plant, K. L. M. Jacobs, J. W. Harger, A. Meskauskas, J. L. Jacobs, J. L. Baxter, A. N. Petrov and J. D. Dinman (2003) RNA, 9, 168–174]. A separate ‘torsional restraint’ model suggests that mRNA pseudoknots act to increase the fraction of ribosomes directed to pause with the upstream heptameric slippery site positioned at the ribosome's A- and P-decoding sites [J. D. Dinman (1995) Yeast, 11, 1115–1127]. Here, experiments using a series of ‘pseudo-pseudoknots’ having different degrees of rotational freedom were used to test this model. The results of this study support the mechanistic hypothesis that −1 ribosomal frameshifting is enhanced by torsional resistance of the mRNA pseudoknot.
has issue date	2005-03-30(xsd:dateTime)
bibo:doi	10.1093/nar/gki329
bibo:pmid	15800212
has license	no-cc
sha1sum (hex)	a77badb297bf4927419481e660ea8f1806ed91b1
schema:url	https://doi.org/10.1093/nar/gki329
resource representing a document's title	Torsional restraint: a new twist on frameshifting pseudoknots
has PubMed Central identifier	PMC1072802
has PubMed identifier	15800212
schema:publication	Nucleic Acids Res
resource representing a document's body	covid:a77badb297bf4927419481e660ea8f1806ed91b1#body_text
is schema:about of	named entity 'address' named entity 'ribosomal frameshifting' named entity 'pseudoknot' named entity '1995' named entity 'twist' named entity 'mRNA' named entity 'enhanced' named entity 'Plant' named entity 'frameshifting' named entity 'denatured' named entity 'frameshifting' named entity 'mRNAs' named entity 'ribosome' named entity 'polyacrylamide' named entity 'RNA' named entity 'nucleotide' named entity 'mRNAs' named entity 'ribosomes' named entity 'Yeast' named entity 'RNA' named entity 'ribosome' named entity 'mRNA' named entity 'Torsional' named entity 'RNaseH' named entity 'stem-loop structures' named entity 'oligonucleotide' named entity 'base pairs' named entity 'frameshift' named entity 'plasmids' named entity 'MgCl' named entity 'P-site' named entity '250 mM' named entity 'mRNA' named entity 'frameshifting' named entity 'RNA' named entity 'molar' named entity 'frameshifting' named entity 'oligo' named entity 'frameshifting' named entity 'frameshifting' named entity 'luciferase' named entity 'pseudoknot' named entity 'mRNAs' named entity 'mutation' named entity 'mRNA' named entity 'hybridized' named entity 'frameshifting' named entity 'pseudoknot' named entity 'reverse transcriptase' named entity 'mRNA' named entity 'frameshifting' named entity 'frameshifting' named entity 'annealed' named entity 'reverse transcriptase' named entity 'molar' named entity 'mRNA' named entity 'ribosome' named entity 'enzyme' named entity 'oligo' named entity 'oligo' named entity 'restriction sites' named entity 'downstream region' named entity 'mRNAs' named entity 'ribosomes' named entity 'anneal' named entity 'mRNA' named entity 'base-paired' named entity 'DNA hybrid' named entity 'frameshifting' named entity 'frameshifting' named entity 'pseudoknot' named entity 'reverse transcriptase' named entity 'oligonucleotide'

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