About: Identification of natural compounds with antiviral activities against SARS-associated coronavirus

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About: Identification of natural compounds with antiviral activities against SARS-associated coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of natural compounds with antiviral activities against SARS-associated coronavirus
Creator	Wang, Hui Wang, Lin Chen, Cong Yu, Jun Tan, Xuehai Zhang, Xiang Li, Shi-You Guo, Hai-Yan Hua, Shi-Neng Li, Rong-Song Xiao, Pei-Gen Zhang, Hai-Qing
Source	Elsevier; Medline; PMC
abstract	Abstract More than 200 Chinese medicinal herb extracts were screened for antiviral activities against Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay for virus-induced cytopathic effect (CPE). Four of these extracts showed moderate to potent antiviral activities against SARS-CoV with 50% effective concentration (EC50) ranging from 2.4±0.2 to 88.2±7.7μg/ml. Out of the four, Lycoris radiata was most potent. To identify the active component, L. radiata extract was subjected to further fractionation, purification, and CPE/MTS assays. This process led to the identification of a single substance lycorine as an anti-SARS-CoV component with an EC50 value of 15.7±1.2nM. This compound has a CC50 value of 14980.0±912.0nM in cytotoxicity assay and a selective index (SI) greater than 900. The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.
has issue date	2005-07-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2005.02.007
bibo:pmid	15885816
has license	els-covid
sha1sum (hex)	a7cb77c6d80a536ff5c0ac3b94142e9c7014b5e6
schema:url	https://doi.org/10.1016/j.antiviral.2005.02.007
resource representing a document's title	Identification of natural compounds with antiviral activities against SARS-associated coronavirus
has PubMed Central identifier	PMC7114104
has PubMed identifier	15885816
schema:publication	Antiviral Research
resource representing a document's body	covid:a7cb77c6d80a536ff5c0ac3b94142e9c7014b5e6#body_text
is schema:about of	named entity 'assay' named entity 'CPE' named entity 'herbal' named entity 'screened' named entity 'selective' covid:arg/a7cb77c6d80a536ff5c0ac3b94142e9c7014b5e6 named entity 'ACUTE' named entity 'CPE' named entity 'ACTIVITIES' named entity 'CYTOPATHIC EFFECT' named entity '1.2' named entity 'GREATER THAN' named entity '2.4' named entity 'SINGLE' named entity '200' named entity 'DRUGS' named entity 'INDUCED' named entity 'TETRAZOLIUM' named entity 'COMPONENT' named entity 'SALT' named entity 'CYTOTOXICITY ASSAY' named entity 'TREATMENT' named entity 'SUBSTANCE' named entity '283' named entity 'PROCESS' named entity '2C5' named entity 'ACTIVE' named entity 'TO IDENTIFY' named entity 'DEVELOPMENT' named entity 'LYCORIS RADIATA' named entity 'USING' named entity '912' named entity 'SARS' named entity 'RESULTS' named entity 'SARS-COV' named entity 'ANTIVIRAL' named entity 'VALUE' named entity 'IDENTIFICATION' named entity 'SARS-ASSOCIATED CORONAVIRUS' named entity 'NATURAL' named entity 'CORONAVIRUS' named entity 'INNER' named entity 'RADIATA' named entity 'ASSAY' named entity 'SELECTIVE' named entity '50%' named entity 'PURIFICATION' named entity 'VIRUS' named entity 'FRACTIONATION' named entity 'CONCENTRATION' named entity 'INDEX' named entity 'SEVERE' named entity 'EXTRACT' named entity 'EFFECTIVE' named entity 'LED' named entity 'MORE THAN' named entity 'MEDICINAL HERB' named entity 'CHINESE' named entity 'ANTIVIRAL' named entity 'IDENTIFICATION' named entity 'EXTRACTS' named entity '900' named entity 'COMPOUND' named entity 'NEW' named entity '7.7' named entity 'RESPIRATORY' named entity 'MODERATE' named entity 'THESE' named entity 'HERBAL' named entity 'LYCORINE'

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