About: COVID-19–Associated Collapsing Focal Segmental Glomerulosclerosis: A Report of 2 Cases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19–Associated Collapsing Focal Segmental Glomerulosclerosis: A Report of 2 Cases
Creator	Larsen, Christopher Nasr, Samih Kemper, Amy Ormsby, Adrian Sharma, Yuvraj Williamson, Sean
source	Medline; PMC
abstract	Collapsing glomerulopathy is an aggressive form of focal segmental glomerulosclerosis with diverse causes. The presence of the apolipoprotein L1 (APOL1) high-risk genotype is a major risk factor for collapsing glomerulopathy in African Americans. Coronavirus disease 2019 (COVID-19) is an emerging pandemic with predominant respiratory manifestations. However, kidney involvement is being frequently noted and is associated with higher mortality. Currently, kidney pathology data for COVID-19 are scant and mostly come from postmortem findings. We report 2 African American patients who developed acute kidney injury and proteinuria in temporal association with COVID-19 infection. Kidney biopsy specimens showed collapsing glomerulopathy, endothelial tubuloreticular inclusions, and acute tubular injury, without evidence by electron microscopy or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in situ hybridization of viral infection of kidney cells. Both patients had the APOL1 high-risk genotype. We propose that collapsing glomerulopathy represents a novel manifestation of COVID-19 infection, especially in people of African descent with APOL1 risk alleles.
has issue date	2020-06-06(xsd:dateTime)
bibo:doi	10.1016/j.xkme.2020.05.005
bibo:pmid	32775990
has license	cc-by-nc-nd
sha1sum (hex)	a7f3dc90b391624d50899902ff6ce60700c07891
schema:url	https://doi.org/10.1016/j.xkme.2020.05.005
resource representing a document's title	COVID-19–Associated Collapsing Focal Segmental Glomerulosclerosis: A Report of 2 Cases
has PubMed Central identifier	PMC7406850
has PubMed identifier	32775990
schema:publication	Kidney Med
resource representing a document's body	covid:a7f3dc90b391624d50899902ff6ce60700c07891#body_text
is schema:about of	named entity 'COVID-19' named entity 'Focal Segmental Glomerulosclerosis' named entity 'infection' named entity 'pulse oximetry' named entity 'HPF' named entity 'glomerulopathy' named entity 'immunofixation' named entity 'infection' named entity 'kidney injury' named entity 'Urinalysis' named entity 'complement C3' named entity 'hiccups' named entity 'abdominal pain' named entity 'respiratory distress' named entity 'infection' named entity 'COVID' named entity 'acute kidney injury' named entity 'antibiotic treatment' named entity 'viral particles' named entity 'complement C3' named entity 'mm Hg' named entity 'glomerulopathy' named entity 'blood pressure' named entity 'urea' named entity 'hemophagocytic syndrome' named entity 'kidney' named entity 'mm Hg' named entity 'autoimmune diseases' named entity 'immunomodulation therapy' named entity 'Kidney biopsy' named entity 'ultrasound' named entity 'hepatitis' named entity 'Kidney biopsy' named entity 'protein' named entity 'Urine culture' named entity 'alleles' named entity 'kidney' named entity 'SARS-CoV-2' named entity 'high-power field' named entity 'vomiting' named entity 'sodium' named entity 'peripheral vascular disease' named entity 'intravenous hydration' named entity 'endothelial' named entity 'kidney function' named entity 'protein' named entity 'podocytes' named entity 'HPF' named entity 'Kidney' named entity 'x-ray' named entity 'inflammation' named entity 'hypoxia' named entity 'abdominal tenderness' named entity 'kidney' named entity 'endothelial' named entity 'corticosteroids' named entity 'hypernatremia' named entity 'prognostic marker' named entity 'high-risk' named entity 'intravenous hydration' named entity 'methylprednisolone' named entity 'clinical symptoms' named entity 'glomerulopathy' named entity 'kidney' named entity 'HPF' named entity 'podocyte' named entity 'HIV' named entity 'glomerulopathy' named entity 'COVID' named entity 'urea' named entity 'poor appetite' named entity 'Interstitial fibrosis' named entity 'acute tubular necrosis' named entity 'hemodynamic' named entity 'protein electrophoresis' named entity 'glomeruli'

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