About: Biophysical approaches for exploring lipopeptide-lipid interactions

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Biophysical approaches for exploring lipopeptide-lipid interactions
Creator	Bertrand, Brandt Conde, Renaud Munoz-Garay, Carlos Munusamy, Sathishkumar
Source	Elsevier; Medline; PMC
abstract	Abstract In recent years, lipopeptides (LPs) have attracted a lot of attention in the pharmaceutical industry due to their broad-spectrum of antimicrobial activity against a variety of pathogens and their unique mode of action. This class of compounds has enormous potential for application as an alternative to conventional antibiotics and for pest control. Understanding how LPs work from a structural and biophysical standpoint through investigating their interaction with cell membranes is crucial for the rational design of these biomolecules. Various analytical techniques have been developed for studying intramolecular interactions with high resolution. However, these tools have been barely exploited in lipopeptide-lipid interactions studies. These biophysical approaches would give precise insight on these interactions. Here, we reviewed these state-of-the-art analytical techniques. Knowledge at this level is indispensable for understanding LPs activity and particularly their potential specificity, which is relevant information for safe application. Additionally, the principle of each analytical technique is presented and the information acquired is discussed. The key challenges, such as the selection of the membrane model are also been briefly reviewed.
has issue date	2020-03-31(xsd:dateTime)
bibo:doi	10.1016/j.biochi.2020.01.009
bibo:pmid	31978418
has license	els-covid
sha1sum (hex)	a806a37a43e32e4d948f2a6f7567bbbb7f94b8d3
schema:url	https://doi.org/10.1016/j.biochi.2020.01.009
resource representing a document's title	Biophysical approaches for exploring lipopeptide-lipid interactions
has PubMed Central identifier	PMC7116911
has PubMed identifier	31978418
schema:publication	Biochimie
resource representing a document's body	covid:a806a37a43e32e4d948f2a6f7567bbbb7f94b8d3#body_text
is schema:about of	named entity 'BIOPHYSICAL' named entity 'potential' named entity 'variety' named entity 'structural' named entity 'interactions' named entity 'resolution' named entity 'Various' named entity 'application' named entity 'barely' named entity 'biophysical' named entity 'rational design' named entity 'biophysical' named entity 'ACTIVITY' named entity 'BIOMOLECULES' named entity 'PRECISE' named entity 'CHALLENGES' named entity 'KNOWLEDGE' named entity 'OF EACH' named entity 'LIPOPEPTIDES' named entity 'YEARS' named entity 'BROAD' named entity 'RELEVANT' named entity 'ANTIMICROBIAL ACTIVITY' named entity 'RECENT' named entity 'MEMBRANE MODEL' named entity 'APPLICATION' named entity 'STUDIES' named entity 'ANALYTICAL TECHNIQUES' named entity 'INTERACTION' named entity 'CONVENTIONAL' named entity 'KEY' named entity 'PEST CONTROL' named entity 'LPS' named entity 'SELECTION' named entity 'VARIOUS' named entity 'INSIGHT' named entity 'A LOT OF' named entity 'MODE OF ACTION' named entity 'WORK' named entity 'SAFE' named entity 'OF-' named entity 'PATHOGENS' named entity 'DUE TO' named entity 'PRINCIPLE' named entity 'SPECTRUM' named entity 'STATE' named entity 'HOW' named entity 'STRUCTURAL' named entity 'INDISPENSABLE' named entity 'INVESTIGATING' named entity 'BIOPHYSICAL' named entity 'LIPID' named entity 'LIPOPEPTIDE' named entity 'LEVEL' named entity 'HERE' named entity 'THESE' named entity 'INTERACTIONS' named entity 'ATTENTION' named entity 'CLASS' named entity 'HIGH RESOLUTION' named entity 'UNIQUE' named entity 'ALTERNATIVE' named entity 'POTENTIAL' named entity 'VARIETY' named entity 'HAVE' named entity 'INTERACTIONS' named entity 'APPROACHES' named entity 'ANTIBIOTICS' named entity 'INFORMATION' named entity 'THEIR' named entity 'ART' named entity 'CELL MEMBRANES' named entity 'SPECIFICITY' named entity 'REVIEWED' named entity 'TOOLS' named entity 'ACQUIRED' named entity 'DESIGN' named entity 'PHARMACEUTICAL INDUSTRY'

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