About: The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road
Creator	Breckpot, Karine Goyvaerts, Cleo Belgium, Counsell, John Leuven, K Tuyaerts, Sandra
Source	Medline; PMC
abstract	Dendritic cells (DCs) are recognized as highly potent antigen-presenting cells that are able to stimulate cytotoxic T lymphocyte (CTL) responses with antitumor activity. Consequently, DCs have been explored as cellular vaccines in cancer immunotherapy. To that end, DCs are modified with tumor antigens to enable presentation of antigen-derived peptides to CTLs. In this review we discuss the use of viral vectors for in situ modification of DCs, focusing on their clinical applications as anticancer vaccines. Among the viral vectors discussed are those derived from viruses belonging to the families of the Poxviridae, Adenoviridae, Retroviridae, Togaviridae, Paramyxoviridae, and Rhabdoviridae. We will further shed light on how the combination of viral vector-based vaccination with T-cell supporting strategies will bring this strategy to the next level.
has issue date	2018-09-11(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.02052
bibo:pmid	30254636
has license	cc-by
sha1sum (hex)	a81fbdb3bc7956412cd686e72115f4cddf1090be
schema:url	https://doi.org/10.3389/fimmu.2018.02052
resource representing a document's title	The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road
has PubMed Central identifier	PMC6141723
has PubMed identifier	30254636
schema:publication	Front Immunol
resource representing a document's body	covid:a81fbdb3bc7956412cd686e72115f4cddf1090be#body_text
is schema:about of	named entity 'antitumor' named entity 'peptides' named entity 'tumor antigens' named entity 'Paramyxoviridae' named entity 'Poxviridae' named entity 'Engineered' named entity 'Virus' named entity 'BENCH' named entity 'STIMULATE' named entity 'PARAMYXOVIRIDAE' named entity 'VACCINATION' named entity 'RHABDOVIRIDAE' named entity 'ANTICANCER' named entity 'SUPPORTING' named entity 'WITH TUMOR' named entity 'DISCUSS' named entity 'ANTIGEN' named entity 'VIRAL VECTOR' named entity 'POXVIRIDAE' named entity 'PEPTIDES' named entity 'RETROVIRIDAE' named entity 'ENABLE' named entity 'DCS' named entity 'DERIVED' named entity 'PRESENTATION' named entity 'COMBINATION' named entity 'HIGHLY' named entity 'VIRAL VECTORS' named entity 'DENDRITIC CELLS' named entity 'CLINICAL' named entity 'HOW' named entity 'CELLULAR' named entity 'THEIR' named entity 'IN SITU' named entity 'CYTOTOXIC T LYMPHOCYTE' named entity 'FAMILIES' named entity 'T-CELL' named entity 'LIGHT' named entity 'FOCUSING' named entity 'RESPONSES' named entity 'TOGAVIRIDAE' named entity 'TUMOR ANTIGENS' named entity 'CANCER IMMUNOTHERAPY' named entity 'STRATEGY' named entity 'MODIFICATION' named entity 'IN VIVO' named entity 'VIRUSES' named entity 'REVIEW' named entity 'STRATEGIES' named entity 'APPLICATIONS' named entity 'VACCINES' named entity 'ADENOVIRIDAE' named entity 'ANTITUMOR ACTIVITY' named entity 'ANTIGEN-PRESENTING CELLS' named entity 'HAVE' named entity 'LEVEL' named entity 'VIRUS' named entity 'BELONGING' named entity 'DENDRITIC CELLS' named entity 'ROAD' named entity 'ENGINEERED' named entity 'BASED' named entity 'MODIFIED' named entity 'END' named entity 'USE OF' named entity 'vaccines' named entity 'vector-based' named entity 'viral' named entity 'DCs' named entity 'level' named entity 'cancer immunotherapy' named entity 'peptides' named entity 'antigen' named entity 'DCs' named entity 'cytotoxic T lymphocyte' named entity 'Togaviridae'

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