About: Animal Model Prescreening: Pre-exposure to SARS-CoV-2 impacts responses in the NHP model

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About: Animal Model Prescreening: Pre-exposure to SARS-CoV-2 impacts responses in the NHP model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Animal Model Prescreening: Pre-exposure to SARS-CoV-2 impacts responses in the NHP model
Creator	Beitzel, Brett Kugelman, Jeffrey Kuehne, Ana Dye, John Hooper, Jay Minogue, Timothy Herbert, Andrew Koehler, Jeffrey Smith, Jeffrey Akers, Kristen Johnston, Sara O'brien, Cecilia Shoemaker, Charles Clements, Tamara Coyne, Susan Delp, Korey Gibson, Kathleen Kuehnert, Paul Ricks, Keersten
source	BioRxiv
abstract	COVID-19 presents herculean challenges to research and scientific communities for producing diagnostic and treatment solutions. Any return to normalcy requires rapid development of countermeasures, with animal models serving as a critical tool in testing vaccines and therapeutics. Animal disease status and potential COVID-19 exposure prior to study execution may severely bias efficacy testing. We developed a toolbox of immunological and molecular tests to monitor countermeasure impact on disease outcome and evaluate pre-challenge COVID-19 status. Assay application showed critical necessity for animal pre-screening. Specifically, real-time PCR results documented pre-exposure of an African Green Monkey prior to SARS-CoV-2 challenge with sequence confirmation as a community-acquired exposure. Longitudinal monitoring of nasopharyngeal swabs and serum showed pre-exposure impacted both viral disease course and resulting immunological response. This study demonstrates utility in a comprehensive pre-screening strategy for animal models, which captured the first documented case of community-acquired, non-human primate infection. One Sentence Summary Pre-exposure to SARS-CoV-2 affects biomarker responses in animal models, highlighting a need for robust pre-screening protocols prior to medical countermeasure studies.
has issue date	2020-07-13(xsd:dateTime)
bibo:doi	10.1101/2020.07.06.189803
has license	biorxiv
sha1sum (hex)	a884c249fa09caa0282b8cd422ffddeac33e5405
schema:url	https://doi.org/10.1101/2020.07.06.189803
resource representing a document's title	Animal Model Prescreening: Pre-exposure to SARS-CoV-2 impacts responses in the NHP model
schema:publication	bioRxiv
resource representing a document's body	covid:a884c249fa09caa0282b8cd422ffddeac33e5405#body_text
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