About: Hyposialylated α1-acid glycoprotein inhibits phagocytosis of feline neutrophils

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About: Hyposialylated α1-acid glycoprotein inhibits phagocytosis of feline neutrophils Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hyposialylated α1-acid glycoprotein inhibits phagocytosis of feline neutrophils
Creator	Ceciliani, F Paltrinieri, S Rossi, G Capitani, L Restelli, L
Source	Elsevier; Medline; PMC
abstract	Abstract Feline α1-acid glycoprotein (fAGP) modifies both its serum concentration and its glycan moiety during diseases. fAGP is hyposialylated in cats with feline infectious peritonitis (FIP), but not in clinically healthy cats or in cats with other diseases. This study was aimed to determine whether hyposialylated fAGP influences phagocytosis. A flow cytometric method based on ingestion of fluoresceinated bacteria and adapted to feline blood was used to assess phagocytosis of leukocytes incubated with ‘non-pathological’ fAGP (purified from sera with normal concentrations of AGP) and ‘pathological’ fAGP (purified from sera with >1.5mg/mL hyposialylated AGP). The flow cytometric method provided repeatable results for neutrophils (coefficients of variations, CVs <15%) but not for monocytes (CVs>20%) which had also a high individual variability. Compared with saline solution and with non-pathological fAGP, pathological fAGP significantly decreased phagocytosis in neutrophils and monocytes. This study demonstrated that hyposialylated fAGP down-regulates the phagocytic activity of feline neutrophils.
has issue date	2013-10-31(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2013.04.026
bibo:pmid	23726663
has license	els-covid
sha1sum (hex)	a8a03b14c70211bd944a5f49bcf9147045492c77
schema:url	https://doi.org/10.1016/j.rvsc.2013.04.026
resource representing a document's title	Hyposialylated α1-acid glycoprotein inhibits phagocytosis of feline neutrophils
has PubMed Central identifier	PMC7126313
has PubMed identifier	23726663
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:a8a03b14c70211bd944a5f49bcf9147045492c77#body_text
is schema:about of	named entity 'FIP' named entity 'concentrations' named entity 'adapted' named entity 'neutrophils' named entity 'monocytes' named entity 'high' named entity 'determine' named entity 'ACID' named entity 'SALINE SOLUTION' named entity 'LEUKOCYTES' named entity 'PHAGOCYTOSIS' named entity 'INGESTION' named entity 'METHOD' named entity 'HEALTHY' named entity 'NORMAL' named entity 'BASED' named entity 'VARIATIONS' named entity 'BACTERIA ' named entity 'BUT' named entity 'INCUBATED' named entity 'NON-PATHOLOGICAL' named entity 'DEMONSTRATED' named entity 'USED' named entity 'ITS' named entity 'AGP' named entity 'CVS' named entity 'VARIABILITY' named entity 'ACTIVITY' named entity 'GLYCAN MOIETY' named entity 'MG%' covid:arg/a8a03b14c70211bd944a5f49bcf9147045492c77 named entity 'FLOW CYTOMETRY' named entity 'MONOCYTES' named entity 'RESULTS' named entity 'ADAPTED' named entity 'SERA' named entity 'CONCENTRATIONS' named entity 'DISEASES' named entity 'BLOOD' named entity 'MODIFIES' named entity 'DETERMINE' named entity '20%' named entity 'CATS' named entity 'NEUTROPHILS' named entity 'NEUTROPHILS' named entity 'PHAGOCYTOSIS' named entity 'FELINE' named entity 'PATHOLOGICAL' named entity 'DOWN-REGULATES' named entity 'DECREASED PHAGOCYTOSIS' named entity 'INDIVIDUAL' named entity 'HIGH' named entity 'FELINE' named entity 'SERUM CONCENTRATION' named entity 'ASSESS' named entity '3E1' named entity 'S T' named entity 'GLYCOPROTEIN' named entity 'GLYCOPROTEIN' named entity 'COMPARED' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'ACID' named entity 'PROVIDED' named entity 'STUDY' named entity 'diseases' named entity 'coefficients' named entity 'CVs' named entity 'peritonitis' named entity 'Acid' named entity 'moiety' named entity 'phagocytosis' named entity 'bacteria' named entity 'FIP' named entity 'Feline infectious peritonitis' named entity 'neutrophils' named entity '20%' named entity 'Flow cytometry'

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