About: Induction of transcription factor Egr-1 gene expression in astrocytoma cells by Murine coronavirus infection

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About: Induction of transcription factor Egr-1 gene expression in astrocytoma cells by Murine coronavirus infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Induction of transcription factor Egr-1 gene expression in astrocytoma cells by Murine coronavirus infection
Creator	Liu, Yin Cai, Yingyun Zhang, Xuming
source	Elsevier; Medline; PMC
abstract	Abstract Mouse hepatitis virus (MHV) causes encephalitis and demyelination in the central nervous system (CNS) of susceptible rodents. Astrocytes are one of the major targets for MHV infection in the CNS, and respond to MHV infection by expressing diverse molecules that may contribute to CNS pathogenesis. Here we characterized the activation of an immediate-early transcription factor Egr-1 by MHV infection in an astrocytoma cell line. We found that the expression of Egr-1 was dramatically increased following virus infection. Using various inhibitors of mitogen-activated protein kinases, we identified that the extracellular signal-regulated kinases 1/2 were involved in the activation of Egr-1 transcription by MHV infection. Experiments with ultraviolet light-inactivated virus revealed that the induction of Egr-1 did not require virus replication and was likely mediated during cell entry. We further found that over-expression of Egr-1 suppressed the expression of BNip3, a pro-apoptotic member of the Bcl-2 family. This finding may provide an explanation for our previously observed down-regulation of BNip3 by MHV infection in astrocytoma cells (Cai, Liu, Yu, and Zhang, Virology 316:104–115, 2003). Furthermore, knockdown of Egr-1 by an siRNA inhibited MHV propagation, suggesting the biological relevance of Egr-1 induction to virus replication. In addition, the persistence/demylinating-positive strains (JHM and A59) induced Egr-1 expression, whereas the persistence/demylinating-negative strain (MHV-2) did not. These results indicate a correlation between the ability of MHVs to induce Egr-1 expression and their ability to cause demyelination in the CNS, which may suggest a potential role for the induction of Egr-1 in viral pathogenesis.
has issue date	2006-11-25(xsd:dateTime)
bibo:doi	10.1016/j.virol.2006.07.012
bibo:pmid	16908043
has license	els-covid
sha1sum (hex)	a91e76329990d31ca420f0c82ceba12a79d0688c
schema:url	https://doi.org/10.1016/j.virol.2006.07.012
resource representing a document's title	Induction of transcription factor Egr-1 gene expression in astrocytoma cells by Murine coronavirus infection
has PubMed Central identifier	PMC1851928
has PubMed identifier	16908043
schema:publication	Virology
resource representing a document's body	covid:a91e76329990d31ca420f0c82ceba12a79d0688c#body_text
is schema:about of	named entity 'member' named entity 'identified' named entity 'replication' named entity 'transcription factor' named entity 'activation' named entity 'Egr-1' named entity 'MURINE CORONAVIRUS' named entity 'TRANSCRIPTION FACTOR' named entity 'ENCEPHALITIS' named entity 'SIRNA' named entity 'A59' named entity 'DOWN-REGULATION' named entity 'STRAINS' named entity 'BIOLOGICAL' named entity 'VIRAL PATHOGENESIS' named entity 'THEIR' named entity 'INFECTION' named entity 'ULTRAVIOLET LIGHT' named entity 'TARGETS' named entity 'IDENTIFIED' named entity 'PROPAGATION' named entity 'MOLECULES' named entity 'EXTRACELLULAR SIGNAL-REGULATED KINASES' named entity 'ASTROCYTES' named entity 'USING' named entity 'VIRUS INFECTION' named entity 'IMMEDIATE' named entity '115' named entity 'REVEALED' named entity 'ONE OF' named entity 'ASTROCYTOMA CELL LINE' named entity 'FINDING' named entity 'CORONAVIRUS INFECTION' named entity 'CAUSE' named entity 'ABILITY' named entity 'EGR-1' named entity 'ASTROCYTOMA CELLS' covid:arg/a91e76329990d31ca420f0c82ceba12a79d0688c named entity 'THESE' named entity 'OUR' named entity 'INDUCED' named entity 'RELEVANCE' named entity 'CHARACTERIZED' named entity 'BNIP3' named entity 'PERSISTENCE' named entity 'MEMBER OF' named entity 'GENE EXPRESSION' named entity 'INDUCTION' named entity 'ADDITION' named entity 'ASTROCYTOMA CELLS' named entity 'SUGGEST' named entity 'BCL-2 FAMILY' named entity 'RESULTS' named entity 'INCREASED' named entity 'ACTIVATION' named entity 'LIKELY' named entity 'ENTRY' named entity 'CONTRIBUTE ' named entity 'INVOLVED' named entity 'VIRUS REPLICATION' named entity 'INACTIVATED' named entity 'HERE' named entity '316' named entity 'NEGATIVE' named entity 'POTENTIAL' named entity 'INDUCTION' named entity 'DEMYELINATION' named entity 'RESPOND TO' named entity 'CAUSES' named entity 'OBSERVED' named entity 'DIVERSE' named entity 'MOUSE HEPATITIS VIRUS' named entity 'PROVIDE' named entity 'SUSCEPTIBLE' named entity 'ZHANG' named entity 'RODENTS' named entity 'APOPTOTIC' named entity 'EGR-1' named entity 'EXPRESSION'

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