About: Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome

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About: Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome
Creator	Cheng, V Tang, B Wu, A Yuen, K Chu, C Zheng, B Sung, J Chan, K Hung, I Peiris, J Wong, M Yuen, Tse, D
Source	Medline; PMC
abstract	The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. Data from daily hematological, biochemical, radiological, and microbiological investigations were prospectively collected, and the correlation of these findings with diarrhea was retrospectively analyzed. Sixty-nine patients (48.6%) developed diarrhea at a mean (± standard deviation [SD]) of 7.6 ± 2.6 days after the onset of symptoms. The diarrhea was most severe at a mean (±SD) of 8.8 ± 2.4 days after onset, with a maximum frequency of 24 episodes per day (median, 5 episodes; range, 3–24 episodes). A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log(10) vs. 1.8 log(10) copies/mL; P = .01) and mortality (6.2 vs. 1.7 log(10) copies/mL; P < .01). However, diarrhea was not associated with mortality. The lung and the gastrointestinal tract may react differently to SARS coronavirus infection. Additional investigation of the role of SARS coronavirus in the pathogenesis of diarrhea in patients with SARS should be conducted.
has issue date	2004-02-15(xsd:dateTime)
bibo:doi	10.1086/382681
bibo:pmid	14765337
has license	no-cc
sha1sum (hex)	a91f106d643a7ab7ee24218f63f6d6310e048ede
schema:url	https://doi.org/10.1086/382681
resource representing a document's title	Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome
has PubMed Central identifier	PMC7107995
has PubMed identifier	14765337
schema:publication	Clin Infect Dis
resource representing a document's body	covid:a91f106d643a7ab7ee24218f63f6d6310e048ede#body_text
is schema:about of	named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'conducted' named entity 'onset' named entity 'copies' named entity 'day' named entity 'severe' named entity 'DIARRHEA' named entity 'OCCURRENCE' named entity 'FINDINGS' named entity 'ASSOCIATED WITH' named entity 'COLLECTED' named entity 'PER DAY' named entity 'CORONAVIRUS INFECTION' named entity 'SIXTY-NINE' named entity 'SARS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'LOG' named entity 'MEAN' named entity 'MORTALITY' named entity 'DAYS' named entity 'INVESTIGATION' named entity '80%' covid:arg/a91f106d643a7ab7ee24218f63f6d6310e048ede named entity 'GASTROINTESTINAL TRACT' named entity 'PATIENTS' named entity '2.4' named entity 'PATHOGENESIS' named entity '2.6' named entity 'LUNG' named entity 'NASOPHARYNGEAL' named entity 'INVESTIGATED' named entity 'ANALYZED' named entity 'PATIENTS' named entity 'NASOPHARYNX' named entity 'VIRAL REPLICATION' named entity 'OBTAINED' named entity 'THESE' named entity 'STANDARD TREATMENT' named entity 'SPECIMENS' named entity 'ENTERIC' named entity 'PATHOGEN' named entity 'DAY' named entity 'REACT' named entity 'SARS CORONAVIRUS' named entity 'COHORT' named entity 'INVESTIGATIONS' named entity 'EPISODES' named entity 'ONSET' named entity 'ASSOCIATED WITH' named entity '8.8' named entity 'TREATED WITH' named entity 'DIARRHEA' named entity 'COPIES' named entity '1.7' named entity 'SEVERE' named entity 'FREQUENCY' named entity 'CORRELATION' named entity '283' named entity 'ONSET OF SYMPTOMS' named entity 'TREATMENT PROTOCOL' named entity 'DAILY' named entity 'RANGE' named entity 'VIRUS LOAD' named entity 'BIOCHEMICAL' named entity '1.8' named entity 'HIGHER' named entity 'CORONAVIRUS' named entity 'STANDARD DEVIATION' named entity 'MAXIMUM'

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