About: Protein oxidation at the air-lung interface

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protein oxidation at the air-lung interface
Creator	Kelly, F Mudway, I
Source	PMC
abstract	Whilst performing its normal functions the lung is required to deal with a range of toxic insults. Whether these are infectious agents, allergens or air pollutants they subject the lung to a range of direct and indirect oxidative stresses. In many instances these challenges lead to oxidative alterations of peptides and proteins within the lung. Measurement of protein oxidation products permits the degree of oxidative stress to be assessed and indicates that endogenous antioxidant defences are overwhelmed. The range of protein oxidation products observed is diverse and the nature and extent of specific oxidation products may inform us about the nature of the damaging ROS and NOS. Recently, there has been a significant shift away from the measurement of these oxidation products simply to establish the presence of oxidative stress, to a focus on identifying specific proteins sensitive to oxidation and establishing the functional consequences of these modifications. In addition the identification of specific enzyme systems to repair these oxidative modifications has lead to the belief that protein function may be regulated through these oxidation reactions. In this review we focus primarily on the soluble protein components of within the surface liquid layer in the lung and the consequence of their undue oxidation.
has issue date	2003-07-31(xsd:dateTime)
bibo:doi	10.1007/s00726-003-0024-x
bibo:pmid	14661098
has license	no-cc
sha1sum (hex)	a92ffafc26e9a0ca675c0715336c042542b2c544
schema:url	https://doi.org/10.1007/s00726-003-0024-x
resource representing a document's title	Protein oxidation at the air-lung interface
has PubMed Central identifier	PMC7101613
has PubMed identifier	14661098
schema:publication	Amino Acids
resource representing a document's body	covid:a92ffafc26e9a0ca675c0715336c042542b2c544#body_text
is schema:about of	named entity 'presence' named entity 'endogenous' named entity 'products' named entity 'simply' named entity 'instances' named entity 'oxidative stress' named entity 'NOS' named entity 'EXTENT OF' named entity 'CONSEQUENCE OF' named entity 'LIQUID LAYER' named entity 'TOXIC' named entity 'REPAIR' named entity 'SURFACE' named entity 'PROTEINS' named entity 'CHALLENGES' named entity 'FOCUS' named entity 'FUNCTIONAL' named entity 'OBSERVED' named entity 'AWAY' named entity 'SENSITIVE TO' named entity 'PERFORMING' named entity 'MEASUREMENT' named entity 'NORMAL' named entity 'ENDOGENOUS' named entity 'protein' named entity 'consequence' named entity 'air pollutants' named entity 'oxidised' named entity 'expression levels' named entity 'sulfhydryl' named entity 'actin' named entity 'sulphoxide' named entity 'respiratory tract' named entity 'protein' named entity 'hydrogen peroxide' named entity 'acute lung injury' named entity 'glutathione' named entity 'oxidation' named entity 'tyrosine residues' named entity 'lipid metabolism' named entity 'glutathione peroxidase' named entity 'ROS' named entity 'glycoprotein' named entity 'spleen' named entity 'nitrite' named entity 'defensins' named entity 'thiol' named entity 'simple diffusion' named entity 'oxidants' named entity 'GSNO' named entity 'glutathione peroxidase' named entity 'loss of function' named entity 'nitrous acid' named entity 'Cantin' named entity 'Uric acid' named entity 'Tocopherol' named entity 'monocytes' named entity 'pathological conditions' named entity 'respiratory tract' named entity 'oxidation' named entity 'ozone' named entity 'nitric oxide' named entity 'ozone' named entity 'plasma pool' named entity 'thiols' named entity 'free radical scavenging' named entity 'hyperoxia' named entity 'amino acids' named entity 'host defense' named entity 'peroxyl radicals' named entity 'oxidative stress' named entity 'ARDS' named entity 'peroxide' named entity 'Phenylalanine' named entity 'metalloproteinase' named entity 'ozone' named entity 'SOD' named entity 'tissue repair' named entity 'hypochlorous acid' named entity 'nitrite'

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