About: Experimental inoculation of equine coronavirus into Japanese draft horses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Experimental inoculation of equine coronavirus into Japanese draft horses
Creator	Bannai, Hiroshi Kinoshita, Yuta Kondo, Takashi Nemoto, Manabu Oue, Yasuhiro Tsujimura, Koji Yamanaka, Takashi Morita, Yoshinori Niwa, Hidekazu Kanno, Toru Katayama, Yoshinari Ueno, Takanori
source	Medline; PMC
abstract	Recently, outbreaks associated with equine coronavirus (ECoV) have occurred in Japan and the United States. While ECoV is likely to be pathogenic to horses, it has not been shown that experimental inoculation of horses with ECoV produces clinical signs of disease. In this study, we inoculated three Japanese draft horses with an ECoV-positive diarrheic fecal sample to confirm infection after inoculation and to investigate the clinical course and virus shedding patterns of ECoV. Virus neutralization tests showed that all three horses became infected with ECoV. Two of the three horses developed clinical signs similar to those observed during ECoV outbreaks, including fever, anorexia, and gastrointestinal dysfunction. All horses excreted a large amount of virus into their feces for more than 9 days after inoculation regardless of the presence or absence of clinical signs, which suggests that feces are an important source of ECoV infection. ECoV was also detected in nasal swabs from all horses, suggesting that respiratory transmission of ECoV may occur. Both symptomatic horses developed viremia, while the asymptomatic horse did not. White blood cell counts and serum amyloid A concentrations changed relative to the clinical condition of the inoculated horses; these may be useful markers for monitoring the clinical status of horses infected with ECoV. This is the first report of induction of clinical signs of ECoV infection in horses by experimental inoculation. These clinical and virological findings should aid further investigation of the pathogenesis of ECoV.
has issue date	2014-08-20(xsd:dateTime)
bibo:doi	10.1007/s00705-014-2205-1
bibo:pmid	25139547
has license	no-cc
sha1sum (hex)	a9c9f1cdd1cb6be4d05ad41038da1ad67cdc2b67
schema:url	https://doi.org/10.1007/s00705-014-2205-1
resource representing a document's title	Experimental inoculation of equine coronavirus into Japanese draft horses
has PubMed Central identifier	PMC7087042
has PubMed identifier	25139547
schema:publication	Arch Virol
resource representing a document's body	covid:a9c9f1cdd1cb6be4d05ad41038da1ad67cdc2b67#body_text
is schema:about of	named entity 'outbreaks' named entity 'While' named entity 'horses' named entity 'CLINICAL SIGNS ' named entity 'INOCULATION' named entity 'EXPERIMENTAL' named entity 'EQUINE CORONAVIRUS' named entity 'CLINICAL' named entity 'FEVER' named entity 'LIKELY' named entity 'EXPERIMENTAL' named entity 'STUDY' named entity 'CONDITION' named entity 'REGARDLESS' named entity 'MARKERS' named entity 'VIRUS' named entity 'INCLUDING' named entity 'VIRUS NEUTRALIZATION' named entity 'ASSOCIATED WITH' named entity 'AID' named entity 'DID' named entity 'RESPIRATORY' named entity 'NASAL SWABS' named entity 'DRAFT' named entity 'WHITE BLOOD CELL' named entity 'BLOOD CELL COUNTS' named entity 'SIMILAR' named entity 'CONFIRM' named entity 'CONCENTRATIONS' named entity 'INOCULATION' named entity 'HORSE' named entity 'POSITIVE' named entity 'TRANSMISSION' named entity 'PATHOGENESIS' named entity 'SOURCE' named entity 'MONITORING' named entity 'ANOREXIA' named entity 'INFECTION' named entity 'GASTROINTESTINAL DYSFUNCTION' named entity 'MORE THAN' named entity 'FECAL' named entity 'CLINICAL STATUS' named entity 'USEFUL' named entity 'VIROLOGICAL' named entity 'UNITED STATES' named entity 'DETECTED' named entity 'DISEASE' named entity 'OBSERVED' named entity 'OUTBREAKS' named entity 'PATTERNS' named entity 'RECENTLY' named entity 'CLINICAL COURSE' named entity 'TO INVESTIGATE' named entity 'REPORT' named entity 'NEUTRALIZATION TESTS' named entity 'INFECTED' named entity 'LARGE AMOUNT' named entity 'JAPANESE' named entity 'PATHOGENIC' named entity 'SAMPLE' named entity 'HORSES' named entity 'IMPORTANT' named entity 'SYMPTOMATIC' named entity 'ASYMPTOMATIC' named entity 'RELATIVE TO' named entity 'PRESENCE' named entity 'THESE' named entity 'OCCUR' named entity 'JAPAN' named entity 'VIREMIA'

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