About: Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

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About: Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients
Creator	Hou, Hongyan Sun, Ziyong Zhang, Bo Li, Yang Chen, Hong Qi, Huan Tao, Sheng-Ce Guo, Shu-Juan Jiang, He-Wei Zhang, Hai-Nan Fan, Xionglin Lai, Dan-Yun Lei, Qing Lin, Xiaosong Sheng, Huiming Wang, Xue-Ning Wu, Jiaoxiang Xu, Zhao-Wei Xue, Jun-Biao Yao, Zongjie Yu, Caizheng Zhang, Yandi Zheng, Yun-Xiao
source	MedRxiv
abstract	Neutralization antibodies and vaccines for treating COVID-19 are desperately needed. For precise development of antibodies and vaccines, the key is to understand which part of SARS-CoV-2 Spike protein is highly immunogenic on a systematic way. We generate a linear epitope landscape of Spike protein by analyzing serum IgG response of 1,051 COVID-19 patients with a peptide microarray. We reveal two regions that rich of linear epitopes, i.e., CTD and a region close to the S2' cleavage site and fusion peptide. Unexpectedly, we find RBD is lack of linear epitope. Besides 3 moderate immunogenic peptides from RBD, 16 highly immunogenic peptides from other regions of Spike protein are determined. These peptides could serve as the base for precise development of antibodies and vaccines for COVID-19 on a systematic level.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1101/2020.07.13.20152587
has license	medrxiv
sha1sum (hex)	a9e617934e8f5e0c46afc9b566f43df0c6f0b565
schema:url	https://doi.org/10.1101/2020.07.13.20152587
resource representing a document's title	Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients
resource representing a document's body	covid:a9e617934e8f5e0c46afc9b566f43df0c6f0b565#body_text
is schema:about of	named entity 'COVID-19' named entity 'VACCINES' named entity 'antibodies' named entity 'highly' named entity 'protein' named entity 'landscape' named entity 'development' named entity 'serum' named entity 'immunogenic' named entity 'cleavage site' named entity 'Spike protein' named entity 'COVID-19' named entity 'patients' named entity 'antibodies' named entity 'medRxiv' named entity 'protein' named entity 'SARS-CoV-2' named entity 'immunogenicity' named entity 'epitopes' named entity 'SARS-CoV' named entity 'IgG' named entity 'Tongren Hospital' named entity 'Homology' named entity 'CB6' named entity 'RBD' named entity 'CC-BY-NC-ND 4.0' named entity 'β-strand' named entity 'linear epitope' named entity 'BSA' named entity 'antibodies' named entity 'human coronaviruses' named entity 'peptides' named entity 'peptides' named entity 'peer review' named entity 'medRxiv' named entity 'peptide' named entity 'CC-BY-NC-ND 4.0' named entity 'SARS-CoV' named entity 'RBD' named entity 'Grace Bio-Labs' named entity 'CB6' named entity 'prophylactic' named entity 'protein' named entity 'ADE' named entity 'Spike protein' named entity 'RBD' named entity 'SARS-CoV' named entity 'protein' named entity 'buried inside' named entity 'SARS-CoV-2' named entity 'peptide microarray' named entity 'monoclonal antibodies' named entity 'N-glycosylation' named entity 'Spike protein' named entity 'protein structure' named entity 'Spike protein' named entity 'Shanghai' named entity 'human coronaviruses' named entity 'centrifugation' named entity 'amino acids' named entity 'Spike protein' named entity 'peer review' named entity 'high affinity'

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