About: Conserved hla binding peptides from five non-structural proteins of sars-cov-2

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About: Conserved hla binding peptides from five non-structural proteins of sars-cov-2—an in silico glance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Conserved hla binding peptides from five non-structural proteins of sars-cov-2—an in silico glance
Creator	Marchan, Jose
source	Elsevier; PMC
abstract	Abstract Coronavirus Disease 2019 (COVID-19) is a dangerous global threat that has no clinically approved treatment yet. Bioinformatics represent an outstanding approach to reveal key immunogenic regions in viral proteins. Here, five non-structural proteins (NSP) of SARS-CoV-2 (NSP7, NSP8, NSP9, NSP12, and NSP13) were screening for potential human leukocyte antigen (HLA) binding peptides. These peptides showed robust viral antigenicity, immunogenicity, and a marked interaction with HLA alleles. Interestingly, several peptides showed affinity by HLA class I (HLA-I) alleles that commonly activates to NK cells. Moreover, HLA-I and HLA class II (HLA-II) binding peptides induced humoral and cell-mediated responses after in silico vaccination. Notably, these peptides are conserved among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). These results may open further in vitro and in vivo investigations to develop novel therapeutic strategies against coronaviral infections.
has issue date	2020-08-13(xsd:dateTime)
bibo:doi	10.1016/j.humimm.2020.08.001
has license	els-covid
sha1sum (hex)	aa24f06d07df439766cb7eea5f3286bf90f45c4b
schema:url	https://doi.org/10.1016/j.humimm.2020.08.001
resource representing a document's title	Conserved hla binding peptides from five non-structural proteins of sars-cov-2—an in silico glance
has PubMed Central identifier	PMC7425717
schema:publication	Human Immunology
resource representing a document's body	covid:aa24f06d07df439766cb7eea5f3286bf90f45c4b#body_text
is schema:about of	named entity 'doi' named entity 'Declarations' named entity 'peptides' named entity 'non-structural proteins' named entity 'doi' named entity 'non-structural proteins' named entity 'peptides' named entity 'SARS-COV-2' named entity 'DRB1*03' named entity 'peptides' named entity 'HLA' named entity 'vaccine' named entity 'HLA class II' named entity 'vaccine' named entity 'protein complex' named entity 'immunoglobulin' named entity 'php' named entity 'HLA' named entity 'non-structural proteins' named entity 'inductor' named entity 'innate immune response' named entity 'RNA polymerase' named entity 'IFN-g' named entity 'peptides' named entity 'viruses' named entity 'hepatitis C virus' named entity 'alleles' named entity 'IFN-g' named entity 'HLA' named entity 'peptide' named entity 'PEP' named entity 'genome replication' named entity 'peptides' named entity 'amino acid sequence' named entity 'HLA' named entity 'peptides' named entity 'FOLD3' named entity 'P65' named entity 'peptides' named entity 'kcal' named entity 'Natural Killer' named entity 'MERS-CoV' named entity 'helicase' named entity 'RNA' named entity 'DRB1' named entity 'vaccine' named entity 'alleles' named entity 'HLA' named entity 'allergenicity' named entity 'helicase' named entity 'immunogenic' named entity 'P38' named entity 'immune responses' named entity 'peptides' named entity 'COVID-19.' named entity 'alleles' named entity 'pathogenesis' named entity 'molecular docking' named entity 'SARS-CoV-2' named entity 'prophylactic' named entity 'P67' named entity 'peptides' named entity 'Nayer' named entity 'immune response' named entity 'peptides' named entity 'peptides' named entity 'toxicity' named entity 'SARS-CoV-2' named entity 'IFN-g' named entity 'P66' named entity 'immune response' named entity 'peptides' named entity 'HLA' named entity 'peptides' named entity 'virus' named entity 'HLA' named entity 'HLA' named entity 'alleles' named entity 'peptides' named entity 'RNA viruses' named entity 'peptides' named entity 'P39' named entity 'HLA'

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