About: Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection
Creator	Hohdatsu, Tsutomu Doki, Tomoyoshi Takano, Tomomi Satoh, Kumi Tanabe, Taishi
Source	Medline; PMC
abstract	Feline infectious peritonitis (FIP) is a viral disease with a high morbidity and mortality by the FIP virus (FIPV, virulent feline coronavirus). Several antiviral drugs for FIP have been identified, but many of these are expensive and not available in veterinary medicine. Hydroxychloroquine (HCQ) is a drug approved by several countries to treat malaria and immune-mediated diseases in humans, and its antiviral effects on other viral infections (e.g., SARS-CoV-2, dengue virus) have been confirmed. We investigated whether HCQ in association with interferon-ω (IFN-ω) is effective for FIPV in vitro. A total of 100 μM of HCQ significantly inhibited the replication of types I and II FIPV. Interestingly, the combination of 100 μM of HCQ and 10(4) U/mL of recombinant feline IFN-ω (rfIFN-ω, veterinary registered drug) increased its antiviral activity against type I FIPV infection. Our study suggested that HCQ and rfIFN-ω are applicable for treatment of FIP. Further clinical studies are needed to verify the combination of HCQ and rIFN-ω will be effective and safe treatment for cats with FIP.
has issue date	2020-05-24(xsd:dateTime)
bibo:doi	10.3390/v12050576
bibo:pmid	32456286
has license	cc-by
sha1sum (hex)	aa305d97b4faceba2d38ec6cda0b7419ebf7f93f
schema:url	https://doi.org/10.3390/v12050576
resource representing a document's title	Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection
has PubMed Central identifier	PMC7290745
has PubMed identifier	32456286
schema:publication	Viruses
resource representing a document's body	covid:aa305d97b4faceba2d38ec6cda0b7419ebf7f93f#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'morbidity' named entity 'FIP' named entity 'verify' named entity 'investigated' named entity 'malaria' named entity 'type I' named entity 'dengue virus' named entity 'Feline' named entity 'MUTATION' named entity 'HYDROXYCHLOROQUINE' named entity 'HIGH' named entity 'ANTIVIRAL ACTIVITY' named entity 'CATS' named entity 'PROMISE' named entity 'DRUG' named entity 'MALARIA' named entity 'MORBIDITY AND MORTALITY' named entity 'INTERFERON' named entity 'PROBABLY' named entity 'FIPV' named entity 'SARS-COV-2' named entity 'LEAD' named entity 'USED' named entity 'ANTIVIRAL RESISTANCE' named entity 'cats' named entity 'FIP' named entity 'FIPV' named entity 'peritonitis' named entity 'resistance' named entity 'expensive' named entity 'great' named entity 'immune-mediated' named entity 'virus' named entity 'recombinant' named entity 'antivirals' named entity 'demonstrated' named entity 'investigated' named entity 'decades' named entity 'needed' named entity 'types I' named entity 'Vitro' named entity 'Hydroxychloroquine' named entity 'FIP' named entity 'FIP' named entity 'Remdesivir' named entity 'infection' named entity 'virulent' named entity 'immune-mediated' named entity 'HCQ' named entity 'feline coronavirus' named entity 'clinical studies' named entity 'viral disease' named entity 'HCQ' named entity 'Feline Coronavirus' named entity 'Antiviral' named entity 'Type I Interferon' named entity 'FIPV' named entity 'FIP' named entity 'pharmacokinetic' named entity 'Fluorescein' named entity 'HCQ' named entity 'rat' named entity 'type I IFN' named entity 'therapeutic effects' named entity 'antiviral activity' named entity 'FIP' named entity 'serotype' named entity 'antiviral' named entity 'Feline infectious peritonitis' named entity 'microscope' named entity 'FIPV' named entity 'Viruses' named entity 'FIP' named entity 'cytotoxicity' named entity 'FIP' named entity 'FIPV'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software