About: Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review

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About: Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review
Creator	Grocholewicz, Katarzyna Nohawica, Michal Nowak, Gerard Wyganowska-Swiatkowska, Marzena
source	Medline; PMC
abstract	By attaching to the angiotensin converting enzyme 2 (ACE2) protein on lung and intestinal cells, Sudden Acute Respiratory Syndrome (SARS-CoV-2) can cause respiratory and homeostatic difficulties leading to sepsis. The progression from acute respiratory failure to sepsis has been correlated with the release of high-mobility group box 1 protein (HMGB1). Lack of effective conventional treatment of this septic state has spiked an interest in alternative medicine. This review of herbal extracts has identified multiple candidates which can target the release of HMGB1 and potentially reduce mortality by preventing progression from respiratory distress to sepsis. Some of the identified mixtures have also been shown to interfere with viral attachment. Due to the wide variability in chemical superstructure of the components of assorted herbal extracts, common motifs have been identified. Looking at the most active compounds in each extract it becomes evident that as a group, phenolic compounds have a broad enzyme inhibiting function. They have been shown to act against the priming of SARS-CoV-2 attachment proteins by host and viral enzymes, and the release of HMGB1 by host immune cells. An argument for the value in a nonspecific inhibitory action has been drawn. Hopefully these findings can drive future drug development and clinical procedures.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.3390/ijms21134639
bibo:pmid	32629817
has license	cc-by
sha1sum (hex)	aa54cee0dbbfd3552465df20b2e05d1e0e6ee693
schema:url	https://doi.org/10.3390/ijms21134639
resource representing a document's title	Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review
has PubMed Central identifier	PMC7370028
has PubMed identifier	32629817
schema:publication	Int J Mol Sci
resource representing a document's body	covid:aa54cee0dbbfd3552465df20b2e05d1e0e6ee693#body_text
is schema:about of	named entity 'RESPIRATORY DISTRESS' named entity 'ALTERNATIVE MEDICINE' named entity 'CORRELATED' covid:arg/aa54cee0dbbfd3552465df20b2e05d1e0e6ee693 named entity 'alternative medicine' named entity 'enzyme' named entity 'HMGB1' named entity 'sepsis' named entity 'HMGB1' named entity 'sepsis' named entity 'angiotensin converting enzyme 2' named entity 'intestinal cells' named entity 'superstructure' named entity 'Sepsis' named entity 'inflammatory response' named entity 'asthmatic' named entity 'Salidroside' named entity 'monocytes' named entity 'bronchial' named entity 'triterpene' named entity 'HMGB1' named entity 'Na+' named entity 'ethanol' named entity 'LPS' named entity 'PGE2' named entity 'NF-κB' named entity 'vascular adhesion molecules' named entity 'serine protease' named entity 'endotoxin' named entity 'MERS-CoV' named entity 'IL-1β' named entity 'Haemagglutinin' named entity 'protease' named entity 'Dang Gui' named entity 'phenolic compounds' named entity 'E. cava' named entity 'sepsis' named entity 'polysaccharide' named entity 'infection' named entity 'glycoproteins' named entity 'NF-κB' named entity 'HMGB1' named entity 'endotoxin' named entity 'lung' named entity 'IL-6' named entity 'lysophosphatidylcholine' named entity 'HMGB1' named entity 'Sirt1' named entity 'protein' named entity 'systemic inflammatory' named entity 'ethanol' named entity 'anti-viral' named entity 'stereoisomer' named entity 'flavonoids' named entity 'anti-inflammatory effect' named entity 'lactone' named entity 'HMGB1' named entity 'endotoxemia' named entity 'homeostasis' named entity 'nucleus' named entity 'fever' named entity 'molecule' named entity 'E. cava' named entity 'SARS-CoV' named entity 'p65' named entity 'viral load' named entity 'viral infection' named entity 'coronavirus' named entity 'HMGB1' named entity 'iNOS' named entity 'NF-κB' named entity 'IL-6' named entity 'polysaccharide' named entity 'anti-inflammatory' named entity 'herbal extracts' named entity 'TNF-α' named entity 'inflammatory responses' named entity 'interferon-stimulated genes'

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