About: Therapeutic Potential of RNA Interference Against Cellular Targets of HIV Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Therapeutic Potential of RNA Interference Against Cellular Targets of HIV Infection
Creator	Li, Kai Li, A Ae, Xiao Zhang, Jia Wu, Ae Chen, Ae Sirois, Ae
Source	PMC
abstract	RNA interference is not only very promising in identifying new targets for drug development, siRNA/shRNA themselves may be directly used as therapeutic agents. In inhibiting viral infections by RNA interference, both viral targets and cellular proteins have been evaluated. Most of the early studies in this field had chosen viral targets for RNA interference. However, recent efforts are mainly focusing on cellular proteins for RNA silencing due to the realization that a variety of viral responses substantially minimize siRNA effects. With the application of siRNA approaching, many new cellular targets relevant to HIV infection have been identified. The value of siRNA/shRNA in the treatment of AIDS is largely dependent on better understanding of the biology of HIV replication. Efforts in the identification of cellular processes with the employment of siRNA/shRNA have shed some new lights on our understanding of how HIV infection occurs. Furthermore, the relative specific effects and simplicity of design makes siRNA/shRNA themselves to be favorable drug leads.
has issue date	2007-09-15(xsd:dateTime)
bibo:doi	10.1007/s12033-007-9000-0
bibo:pmid	17952669
has license	no-cc
sha1sum (hex)	aa7d24497d4f61b9a8d537c342923f59bae8fe79
schema:url	https://doi.org/10.1007/s12033-007-9000-0
resource representing a document's title	Therapeutic Potential of RNA Interference Against Cellular Targets of HIV Infection
has PubMed Central identifier	PMC7091338
has PubMed identifier	17952669
schema:publication	Mol Biotechnol
resource representing a document's body	covid:aa7d24497d4f61b9a8d537c342923f59bae8fe79#body_text
is schema:about of	named entity 'lights' named entity 'cellular proteins' named entity 'promising' named entity 'RNA silencing' named entity 'targets' named entity 'replication' named entity 'responses' named entity 'targets' named entity 'RELATIVE' named entity 'FOCUSING' named entity 'THERAPEUTIC AGENTS' covid:arg/aa7d24497d4f61b9a8d537c342923f59bae8fe79 named entity 'siRNA' named entity 'early' named entity 'HIV' named entity 'shRNA' named entity 'cellular' named entity 'evaluated' named entity 'type I interferons' named entity 'ecdysone' named entity 'reverse transcription' named entity 'HIV-1' named entity 'antisense RNA' named entity 'With' named entity 'Targets' named entity 'therapeutic agents' named entity 'RNA silencing' named entity 'siRNA' named entity 'AIDS' named entity 'drug development' named entity 'RNA interference' named entity 'siRNA' named entity 'genome' named entity 'dominant-negative' named entity 'growth factors' named entity 'T-cell' named entity 'siRNAs' named entity 'cytoplasm' named entity 'Intracellular' named entity 'shRNA' named entity 'CD8' named entity 'HIV' named entity 'viral replication' named entity 'astrocytes' named entity 'liposome' named entity 'toxicity' named entity 'chemokine' named entity 'enzyme' named entity 'HIV' named entity 'small nuclear RNAs' named entity 'siRNA' named entity 'drug development' named entity 'RNAi' named entity 'PARP-1' named entity 'CD4 cells' named entity 'siRNA' named entity 'HIV-1' named entity 'HIV' named entity 'cDNA' named entity 'RNA interference' named entity 'transduce' named entity 'mutants' named entity 'protein' named entity 'HIV-1' named entity 'toxicity' named entity 'host cells' named entity 'siRNA' named entity 'liposome' named entity 'HIV-1 infection' named entity 'siRNA' named entity 'small molecule' named entity 'Cul5' named entity 'target site' named entity 'CDKN1A' named entity 'CCR5'

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