About: Prolonged presence of effector‐memory CD8 T cells in the central nervous system after dengue virus encephalitis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Prolonged presence of effector‐memory CD8 T cells in the central nervous system after dengue virus encephalitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Prolonged presence of effector‐memory CD8 T cells in the central nervous system after dengue virus encephalitis
Creator	Van Der Most, Robbert Ahmed, Ra® Murali-Krishna, Kaja
source	Medline; PMC
abstract	Dengue virus infection in the central nervous system (CNS) of immunized mice results in a strong influx of CD8 T cells into the brain. Whereas the kinetics of the splenic antiviral response are conventional, i.e. expansion followed by a rapid drop in the frequency of specific CD8 T cells, dengue virus‐specific CD8 T cells are retained in the CNS at a high frequency. These CD8 T cells display a partially activated phenotype (CD69(high), Ly‐6A/E(high), CD62L(low)), characteristic for effector‐memory T cells. CD43 expression, visualized by staining with the 1B11 mAb, decreased in time, suggesting that these persisting CD8 T cells differentiated into memory cells. These data add to the growing evidence implicating the CNS as a non‐lymphoid tissue capable of supporting prolonged T cell survival/maintenance.
has issue date	2003-01-01(xsd:dateTime)
bibo:doi	10.1093/intimm/dxg009
bibo:pmid	12502732
has license	no-cc
sha1sum (hex)	aa7d2c9cab0d8205ed9c65297f5803499825d90f
schema:url	https://doi.org/10.1093/intimm/dxg009
resource representing a document's title	Prolonged presence of effector‐memory CD8 T cells in the central nervous system after dengue virus encephalitis
has PubMed Central identifier	PMC7108596
has PubMed identifier	12502732
schema:publication	Int Immunol
resource representing a document's body	covid:aa7d2c9cab0d8205ed9c65297f5803499825d90f#body_text
is schema:about of	named entity 'frequency' named entity 'These' named entity 'high' named entity 'high frequency' named entity 'T cells' named entity 'CD8' covid:arg/aa7d2c9cab0d8205ed9c65297f5803499825d90f named entity 'brain' named entity 'speci' named entity 'activated' named entity 'CNS' named entity 'MEL' named entity 'CD8' named entity 'virus infection' named entity 'antiviral' named entity 'drop' named entity 'staining' named entity 'presence' named entity 'splenic' named entity 'staining' named entity 'CD8 T cells' named entity 'CD69' named entity 'phenotype' named entity 'central nervous' named entity 'effector' named entity 'human infection' named entity 'viral RNA' named entity 'CD69' named entity 'CD43' named entity 'CNS' named entity 'dengue virus' named entity 'CD69' named entity 'vaccination' named entity 'effector T cells' named entity 'CD8 T cells' named entity 'dengue virus' named entity 'immunization' named entity 'mAb' named entity 'memory cells' named entity 'Phenotypically' named entity 'spleen' named entity 'memory cells' named entity 'CD43' named entity 'antiviral' named entity 'memory cells' named entity 'IFN-g' named entity 'up-regulated' named entity 'IFN-g' named entity 'recombinant virus' named entity 'MHV' named entity 'vaccination' named entity 'CD69' named entity 'CD62L' named entity 'BALB/c' named entity 'CD8 T cell' named entity 'antibiotics' named entity 'phenotype' named entity 'memory cells' named entity 'dengue' named entity 'amino acids' named entity 'CNS' named entity 'CD69' named entity 'neurovirulent' named entity 'antigen' named entity 'virus' named entity 'CD69' named entity 'CD8 T cells' named entity 'acute infection' named entity 'A20 cells' named entity 'dengue' named entity 'antibody' named entity 'San Diego' named entity 'antibodies' named entity 'cellular immune response' named entity 'CD8 T cells' named entity 'CD8 T cells' named entity 'CD4 T cell' named entity 'thymocytes' named entity 'central memory'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software