About: SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

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About: SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia
Creator	Zhou, Yuan Boinon, Lisa Cai, Song Gomez, Kimberly Gonzalez, Kerry Ibrahim, Mohab Khanna, Rajesh Luo, Shizhen Martin, Laurent Moutal, Aubin Patwardhan, Amol Perez-Miller, Samantha Ran, Dongzhi Stratton, Harrison
Source	BioRxiv
abstract	Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2’s Spike protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and vascular endothelial growth factor-A (VEGF-A) – a pro-nociceptive and angiogenic factor, bind NRP-1, we tested if Spike could block VEGF-A/NRP-1 signaling. VEGF-A–triggered sensory neuronal firing was blocked by Spike protein and NRP-1 inhibitor EG00229. Pro-nociceptive behaviors of VEGF-A were similarly blocked via suppression of spontaneous spinal synaptic activity and reduction of electrogenic currents in sensory neurons. Remarkably, preventing VEGF-A/NRP-1 signaling was antiallodynic in a neuropathic pain model. A ‘silencing’ of pain via subversion of VEGF-A/NRP-1 signaling may underlie increased disease transmission in asymptomatic individuals.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1101/2020.07.17.209288
has license	biorxiv
sha1sum (hex)	aacff4cad047561b6f5993a9f0f300af8fe0de14
schema:url	https://doi.org/10.1101/2020.07.17.209288
resource representing a document's title	SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia
schema:publication	bioRxiv
resource representing a document's body	covid:aacff4cad047561b6f5993a9f0f300af8fe0de14#body_text
is schema:about of	named entity 'VEGF-A' named entity 'receptor' named entity 'continues' named entity 'severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'Neuropilin-1' named entity 'PDB' named entity 'preclinical' named entity 'PyMol' named entity 'VEGFR1' named entity 'nociceptor' named entity 'presynaptic' named entity 'VEGF-A' named entity 'NRP-1' named entity 'allodynia' named entity 'NRP-1' named entity 'furin' named entity 'ligand' named entity 'San Diego' named entity 'opioids' named entity 'spontaneous activity' named entity 'Spike protein' named entity 'rat model' named entity 'DRG' named entity 'VEGF-A' named entity 'NRP-1' named entity 'Institutional Animal Care and Use Committee' named entity 'PBS' named entity 'neuropathic pain' named entity 'NRP-1' named entity 'dorsal horn' named entity 'Spike protein' named entity 'Millipore' named entity 'NaV1.7' named entity 'dorsum' named entity 'COVID' named entity 'virus' named entity 'hyperalgesia' named entity 'ligands' named entity 'plantar' named entity 'Spike protein' named entity 'bevacizumab' named entity 'VEGF-A' named entity 'sodium channel' named entity 'allodynia' named entity '10 nM' named entity 'NRP-1' named entity 'ligand' named entity 'SARS-CoV-2' named entity 'PBS' named entity 'Spike protein' named entity 'Schrödinger, LLC' named entity 'SARS-CoV-2' named entity 'N-type' named entity 'analgesic' named entity 'Spike protein' named entity 'NRP-1' named entity 'Spike protein' named entity 'VEGF-A' named entity 'allodynia' named entity 'NRP-1' named entity 'CNS' named entity 'recombinant' named entity 'asymptomatic' named entity 'intrathecal' named entity 'streptomycin sulfate' named entity 'COVID-19' named entity 'ligand' named entity 'Sema3A' named entity 'COVID' named entity 'experimental groups'

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