About: Validity of the Common Cold Questionnaire (CCQ) in Asthma Exacerbations

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Validity of the Common Cold Questionnaire (CCQ) in Asthma Exacerbations
Creator	Grissell, Terry Powell, Heather Smart, Joanne Gibson, Peter Hensley, Michael Shafren, Darren Wood, Lisa
source	Medline; PMC
abstract	BACKGROUND: The common cold questionnaire (CCQ) is used to discriminate those with and without a viral infection. Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing. METHODOLOGY/PRINCIPAL FINDINGS: We studied subjects (≥7 yrs) admitted to hospital with acute asthma and diagnosed as positive (n = 63), or negative to viral infection (n = 27) according to molecular and virological testing from respiratory samples. CCQ, asthma history and asthma control questionnaires were completed and repeated 4–6 weeks later. Sensitivity, specificity, and response to change of the CCQ were assessed by receiver operator curve (ROC) analysis and effect size calculation respectively. The CCQ did not discriminate between viral and non-viral infection for subjects with asthma (sensitivity = 76.2%; specificity = 29.6%). ROC analysis could not differentiate between positive or negative virus in subjects with asthma. The CCQ had a large response to change following recovery (effect size = 1.01). 39% of subjects recovering from viral exacerbation remained positive to virological testing at follow-up despite improvement in clinical symptoms. The CCQ reflected clinical improvement in these subjects, thus providing additional information to complement virological testing. CONCLUSIONS/SIGNIFICANCE: The CCQ is a useful instrument for monitoring response to viral infection in people with asthma. Reliable differentiation between viral and non-viral asthma exacerbations was not achieved with the CCQ and requires specific virological testing. When combined with virological testing, the CCQ should be a useful outcome measure for evaluating therapies in viral-induced asthma.
has issue date	2008-03-19(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0001802
bibo:pmid	18350141
has license	cc-by
sha1sum (hex)	ab54f13666ed771c15684d73ff6bcc7c92b8ae05
schema:url	https://doi.org/10.1371/journal.pone.0001802
resource representing a document's title	Validity of the Common Cold Questionnaire (CCQ) in Asthma Exacerbations
has PubMed Central identifier	PMC2266793
has PubMed identifier	18350141
schema:publication	PLoS One
resource representing a document's body	covid:ab54f13666ed771c15684d73ff6bcc7c92b8ae05#body_text
is schema:about of	named entity 'asthma' named entity 'detect' named entity 'ASTHMA EXACERBATION' named entity 'BACKGROUND' named entity 'AIM' named entity 'DISCRIMINATE' named entity 'VALIDITY' named entity 'CONFIRMED BY' named entity 'TESTING' named entity 'VIRAL' named entity 'USED' named entity 'QUESTIONNAIRE' named entity 'ITS' named entity 'COMMON COLD' named entity 'ASTHMA EXACERBATIONS' named entity 'ABILITY' named entity 'UNKNOWN' named entity 'OUR' named entity 'MONITOR' named entity 'ASSESS' named entity 'COMMON COLD' named entity 'RECOVERY' named entity 'INDUCED' named entity 'VIRAL INFECTION' named entity 'ACUTE ASTHMA' named entity 'QUESTIONNAIRE' named entity 'USEFULNESS' named entity 'VIROLOGICAL' named entity 'PEOPLE' named entity 'TO DETECT' covid:arg/ab54f13666ed771c15684d73ff6bcc7c92b8ae05 named entity 'assess' named entity 'virological' named entity 'viral infection' named entity 'Asthma Exacerbations' named entity 'asthma' named entity 'virus' named entity 'acute asthma' named entity 'asthma' named entity 'FEV' named entity 'Common Cold Unit' named entity 'significant difference' named entity 'asthma exacerbations' named entity 'FEV' named entity 'virus infection' named entity 'respiratory symptoms' named entity 'Eppendorf AG' named entity 'antiviral' named entity 'ROC analysis' named entity 'virus' named entity 'acute exacerbation' named entity 'ROC analysis' named entity 'asthma' named entity 'respiratory epithelium' named entity 'spirometry' named entity 'FEV' named entity 'respiratory syncytial virus' named entity 'beta agonist' named entity 'rhinovirus' named entity 'non-infectious' named entity 'Influenza' named entity 'asthma' named entity 'SARS coronavirus' named entity 'virus' named entity 'human metapneumovirus' named entity 'virus' named entity 'RNA' named entity 'non-parametric' named entity 'viral infection' named entity 'acute asthma' named entity 'virus' named entity 'asthma' named entity 'Lower respiratory' named entity 'lower respiratory tract' named entity 'viral infection'

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